{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T02:32:58Z","timestamp":1790476378768,"version":"4.1.0"},"reference-count":5,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,5,27]],"date-time":"2023-05-27T00:00:00Z","timestamp":1685145600000},"content-version":"vor","delay-in-days":146,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acute Medicine &amp; Surgery"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study aimed to investigate the association of early vasopressor initiation with improved septic shock outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This multicenter observational study was conducted in 17 intensive care units in Japan and included adult patients with sepsis admitted to the intensive care unit from July 2019 to August 2020 and treated with vasopressor therapy. Patients were divided into the early vasopressor group (\u22641\u2009h from sepsis recognition) and the delayed vasopressor group (&gt;1\u2009h). The impact of early vasopressor administration on risk\u2010adjusted in\u2010hospital mortality was estimated using logistic regression analyses adjusted by an inverse probability of treatment weighting analysis with propensity scoring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 97 patients, 67 received vasopressor therapy within 1\u2009h from sepsis recognition and 30 received vasopressor after 1\u2009h. In\u2010hospital mortality was 32.8% in the early vasopressor group and 26.7% in the delayed vasopressor group (<jats:italic>p<\/jats:italic>\u2009=\u20090.543). The adjusted odds ratio for in\u2010hospital mortality was 0.76 (95% confidence interval 0.17\u20133.29) when comparing patients in the early vasopressor with those in the delayed vasopressor group. The fit curve from the mixed\u2010effects model showed a relatively lower trend toward an infusion volume over time in the early vasopressor group than in the delayed vasopressor group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study did not reach a definitive conclusion for early vasopressor administration. However, early vasopressor administration may help avoid volume overload in the long course of sepsis care.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ams2.852","type":"journal-article","created":{"date-parts":[[2023,5,27]],"date-time":"2023-05-27T07:44:08Z","timestamp":1685173448000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Early versus delayed vasopressor administration in patients with septic shock"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8343-5151","authenticated-orcid":false,"given":"Toshikazu","family":"Abe","sequence":"first","affiliation":[{"name":"Department of Emergency and Critical Care Medicine Tsukuba Memorial Hospital  Tsukuba Japan"},{"name":"Health Services Research and Development Center University of Tsukuba  Tsukuba Japan"},{"name":"Department of Health Services Research, Faculty of Medicine University of Tsukuba  Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8357-0313","authenticated-orcid":false,"given":"Yutaka","family":"Umemura","sequence":"additional","affiliation":[{"name":"Division of Trauma and Surgical Critical Care Osaka General Medical Center  Osaka Japan"},{"name":"Department of Traumatology and Acute Critical Medicine Osaka University Graduate School of Medicine  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Ogura","sequence":"additional","affiliation":[{"name":"Department of Traumatology and Acute Critical Medicine Osaka University Graduate School of Medicine  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9232-5782","authenticated-orcid":false,"given":"Shigeki","family":"Kushimoto","sequence":"additional","affiliation":[{"name":"Division of Emergency and Critical Care Medicine Tohoku University Graduate School of Medicine  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8823-8440","authenticated-orcid":false,"given":"Seitaro","family":"Fujishima","sequence":"additional","affiliation":[{"name":"Center for General Medicine Education Keio University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daizoh","family":"Saitoh","sequence":"additional","affiliation":[{"name":"Division of Traumatology Research Institute, National Defense Medical College  Tokorozawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Gando","sequence":"additional","affiliation":[{"name":"Department of Acute and Critical Care Medicine Sapporo Tokushukai Hospital  Sapporo Japan"},{"name":"Department of Anesthesiology and Critical Care Medicine Hokkaido University Faculty of Medicine  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-021-06506-y"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2022.01.063"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201806-1034OC"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000005363"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-019-0498-7"}],"container-title":["Acute Medicine &amp; Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ams2.852","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T00:43:47Z","timestamp":1705020227000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ams2.852"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":5,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1002\/ams2.852"],"URL":"https:\/\/doi.org\/10.1002\/ams2.852","archive":["Portico"],"relation":{},"ISSN":["2052-8817","2052-8817"],"issn-type":[{"value":"2052-8817","type":"print"},{"value":"2052-8817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"2023-01-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e852"}}