{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:18:25Z","timestamp":1757701105940,"version":"3.41.2"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"vor","delay-in-days":212,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acute Medicine &amp; Surgery"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Calcium channel blockers and angiotensin II receptor blockers are commonly prescribed to treat hypertension. Massive overdoses can cause both distributive and cardiogenic shock because of their effects on vascular smooth muscles and severe myocardial depression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Presentation<\/jats:title><jats:p>We present the case of a 46\u2010year\u2010old man who was brought to our emergency department after ingesting 1210\u2009mg amlodipine and 936\u2009mg candesartan. The patient's hemodynamic status deteriorated despite treatment with vasopressors, calcium gluconate, and hyperinsulinemia\u2010euglycemia therapy with mechanical ventilation. Venoarterial extracorporeal membrane oxygenation was initiated for refractory shock. The patient was weaned off extracorporeal membrane oxygenation on day 5 and discharged on day 18 of hospitalization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>When medical therapies are ineffective, aggressive venoarterial extracorporeal membrane oxygenation should be considered for the management of refractory shock in the setting of calcium channel blocker with angiotensin II receptor blocker overdose.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ams2.878","type":"journal-article","created":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T13:34:38Z","timestamp":1690896878000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Intoxication with massive doses of amlodipine and candesartan requiring venoarterial extracorporeal membrane oxygenation"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1772-5839","authenticated-orcid":false,"given":"Minagawa","family":"Yusuke","sequence":"first","affiliation":[{"name":"Department of Emergency and Critical Care Medicine Saiseikai Utsunomiya Hospital  Utsunomiya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yamana","family":"Hidetoshi","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine National Hospital Organization Mito Medical Center  Mito Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9160-0241","authenticated-orcid":false,"given":"Tsutsumi","family":"Yusuke","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine National Hospital Organization Mito Medical Center  Mito Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ishigami","family":"Koji","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine National Hospital Organization Mito Medical Center  Mito Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Togo","family":"Masahito","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine National Hospital Organization Mito Medical Center  Mito Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuda","family":"Susumu","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine National Hospital Organization Mito Medical Center  Mito Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2525-4985","authenticated-orcid":false,"given":"Ogura","family":"Takayuki","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine Saiseikai Utsunomiya Hospital  Utsunomiya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-7176.2011.00513.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(98)00461-5"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199222010-00003"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2006.02.051"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/15563650.2018.1491985"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/15563650.2013.800875"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2006.04599.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/15563650.2020.1826504"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/15563650.2021.1945082"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000003819"}],"container-title":["Acute Medicine &amp; Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ams2.878","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T00:45:28Z","timestamp":1705020328000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ams2.878"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1002\/ams2.878"],"URL":"https:\/\/doi.org\/10.1002\/ams2.878","archive":["Portico"],"relation":{},"ISSN":["2052-8817","2052-8817"],"issn-type":[{"type":"print","value":"2052-8817"},{"type":"electronic","value":"2052-8817"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"2023-04-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e878"}}