{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T07:52:07Z","timestamp":1753861927538,"version":"3.41.2"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T00:00:00Z","timestamp":1713312000000},"content-version":"vor","delay-in-days":107,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP22K21143"],"award-info":[{"award-number":["JP22K21143"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016867","name":"ZOLL Foundation","doi-asserted-by":"publisher","award":["2022"],"award-info":[{"award-number":["2022"]}],"id":[{"id":"10.13039\/100016867","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acute Medicine &amp; Surgery"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>We aimed to investigate the association between estimated glomerular filtration rate and prognosis in out\u2010of\u2010hospital cardiac arrest patients and explore the heterogeneity of the association.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients experiencing out\u2010of\u2010hospital cardiac arrest due to medical causes and registered in the JAAM\u2010OHCA Registry between June 2014 and December 2019 were stratified into shockable rhythm, pulseless electrical activity, and asystole groups according to the cardiac rhythm at the scene. The primary outcome was a 1\u2010month favorable neurological status. Adjusted odds ratios with 95% confidence intervals were calculated to investigate the association between estimated glomerular filtration rate and outcomes using a logistic model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 19,443 patients included, 2769 had initial shockable rhythm at the scene, 5339 had pulseless electrical activity, and 11,335 had asystole. As the estimated glomerular filtration rate decreased, the adjusted odds ratio for a 1\u2010month favorable neurological status decreased among those with initial shockable rhythm (estimated glomerular filtration rate, adjusted odds ratio [95% CI]: 45\u201359\u2009mL\/min\/1.73\u2009m<jats:sup>2<\/jats:sup>, 0.61 [0.47\u20130.79]; 30\u201344\u2009mL\/min\/1.73\u2009m<jats:sup>2<\/jats:sup>, 0.45 [0.32\u20130.62]; 15\u201329\u2009mL\/min\/1.73\u2009m<jats:sup>2<\/jats:sup>, 0.35 [0.20\u20130.63]; and &lt;15\u2009mL\/min\/1.73\u2009m<jats:sup>2<\/jats:sup>, 0.14 [0.07\u20130.27]). Estimated glomerular filtration rate was associated with neurological outcomes in patients aged &lt;65\u2009years with initial shockable rhythm but not in those aged &gt;65\u2009years or patients with initial pulseless electrical activity or asystole.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The estimated glomerular filtration rate is associated with neurological prognosis in out\u2010of\u2010hospital cardiac arrest patients with initial shockable rhythm at the scene but not in those with initial non\u2010shockable rhythm.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ams2.952","type":"journal-article","created":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T05:19:25Z","timestamp":1713417565000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between <scp>eGFR<\/scp> and neurological outcomes among patients with out\u2010of\u2010hospital cardiac arrest: A nationwide prospective study in Japan"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0026-7437","authenticated-orcid":false,"given":"Kenji","family":"Kandori","sequence":"first","affiliation":[{"name":"Department of Emergency and Critical Care Medicine Japanese Red Cross Society, Kyoto Daini Hospital  Kyoto Japan"},{"name":"Department of Legal Medicine Shiga University of Medical Science  Otsu, Shiga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8112-1397","authenticated-orcid":false,"given":"Asami","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine Japanese Red Cross Society, Kyoto Daini Hospital  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Kyoto Prefectural University of Medicine  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4068-0306","authenticated-orcid":false,"given":"Tasuku","family":"Matsuyama","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Kyoto Prefectural University of Medicine  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0107-0580","authenticated-orcid":false,"given":"Tetsuhisa","family":"Kitamura","sequence":"additional","affiliation":[{"name":"Division of Environmental Medicine and Population Sciences, Department of Social and Environmental Medicine, Graduate School of Medicine Osaka University  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromichi","family":"Narumiya","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine Japanese Red Cross Society, Kyoto Daini Hospital  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryoji","family":"Iizuka","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine Japanese Red Cross Society, Kyoto Daini Hospital  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahito","family":"Hitosugi","sequence":"additional","affiliation":[{"name":"Department of Legal Medicine Shiga University of Medical Science  Otsu, Shiga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yohei","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Preventive Services, Graduate School of Medicine Kyoto University  Kyoto Japan"},{"name":"Health Services and Systems Research, Duke\u2010NUS Medical School National University of Singapore  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2016.10.018"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra054415"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2019.06.291"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-18-0631"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjacc\/zuaa018"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2022.10.006"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9572(01)00381-1"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ams2.340"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2008.12.034"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-018-1025-4"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.32.1.128"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01627-8"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2020.101151"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2013.10.043"}],"container-title":["Acute 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