{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T07:51:55Z","timestamp":1753861915629,"version":"3.41.2"},"reference-count":7,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T00:00:00Z","timestamp":1713830400000},"content-version":"vor","delay-in-days":113,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acute Medicine &amp; Surgery"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Factor Xa inhibitors are direct oral anticoagulants that are extremely useful in clinical applications, safe, and do not require dose adjustment. It is desirable to be able to monitor their effects in the event of hemorrhagic complications requiring neutralization. However, it is difficult to monitor their activity and neutralization using conventional coagulation tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Presentation<\/jats:title><jats:p>We report three patients taking factor Xa inhibitors who underwent rotational thromboelastography (ROTEM) monitoring before and after neutralization with andexanet alfa. All three patients had hemorrhagic complications that required neutralization of their factor Xa inhibitors using andexanet alfa. One ROTEM parameter, the EXTEM clotting time (EXTEM\u2010CT), was immediately shortened after andexanet alfa bolus administration, without subsequent extension of the EXTEM\u2010CT assessed 4\u2009h after the bolus dose.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ROTEM parameters, particularly EXTEM\u2010CT, might be useful for monitoring neutralization of factor Xa inhibitors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ams2.954","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T08:35:19Z","timestamp":1713861319000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Three cases of neutralization of factor Xa inhibitors with andexanet alfa under rotational thromboelastography monitoring"],"prefix":"10.1002","volume":"11","author":[{"given":"Takeshi","family":"Yagi","sequence":"first","affiliation":[{"name":"Advanced Medical Emergency and Critical Care Center Yamaguchi University Hospital  Ube Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reina","family":"Kawano","sequence":"additional","affiliation":[{"name":"Advanced Medical Emergency and Critical Care Center Yamaguchi University Hospital  Ube Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuto","family":"Tomokage","sequence":"additional","affiliation":[{"name":"Advanced Medical Emergency and Critical Care Center Yamaguchi University Hospital  Ube Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Ayata","sequence":"additional","affiliation":[{"name":"Advanced Medical Emergency and Critical Care Center Yamaguchi University Hospital  Ube Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasutaka","family":"Koga","sequence":"additional","affiliation":[{"name":"Advanced Medical Emergency and Critical Care Center Yamaguchi University Hospital  Ube Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kotaro","family":"Kaneda","sequence":"additional","affiliation":[{"name":"Advanced Medical Emergency and Critical Care Center Yamaguchi University Hospital  Ube Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motoki","family":"Fujita","sequence":"additional","affiliation":[{"name":"Advanced Medical Emergency and Critical Care Center Yamaguchi University Hospital  Ube Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nanami","family":"Yamanaka","sequence":"additional","affiliation":[{"name":"Department of Neurology and Clinical Neuroscience Yamaguchi University Graduate School of Medicine  Ube Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomasa","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Yamaguchi University School of Medicine  Ube Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryosuke","family":"Tsuruta","sequence":"additional","affiliation":[{"name":"Advanced Medical Emergency and Critical Care Center Yamaguchi University Hospital  Ube Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1107039"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1009638"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1310907"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.12744"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1450-8178"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-023-04327-7"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.030565"}],"container-title":["Acute Medicine &amp; Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ams2.954","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T10:47:03Z","timestamp":1735555623000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ams2.954"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":7,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1002\/ams2.954"],"URL":"https:\/\/doi.org\/10.1002\/ams2.954","archive":["Portico"],"relation":{},"ISSN":["2052-8817","2052-8817"],"issn-type":[{"type":"print","value":"2052-8817"},{"type":"electronic","value":"2052-8817"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"2024-01-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e954"}}