{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:36:00Z","timestamp":1791894960600,"version":"4.3.4"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2001,11,15]],"date-time":"2001-11-15T00:00:00Z","timestamp":1005782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2002,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A cardinal feature of impaired skeletal muscle oxidative metabolism in mitochondrial myopathies is a limited ability to increase the extraction of O<jats:sub>2<\/jats:sub> from blood relative to the increase in O<jats:sub>2<\/jats:sub> delivery by the circulation during exercise. We investigated whether aerobic forearm exercise would result in an abnormal increase in venous effluent O<jats:sub>2<\/jats:sub> in patients with impaired skeletal muscle oxidative phosphorylation attributable to mitochondrial disease. We monitored the partial pressure of O<jats:sub>2<\/jats:sub> (P<jats:sc>O<\/jats:sc><jats:sub>2<\/jats:sub>) in cubital venous blood at rest, during handgrip exercise, and during recovery in 13 patients with mitochondrial myopathy and exercise intolerance and in 13 healthy control and 11 patient control subjects. Resting and recovery venous effluent P<jats:sc>O<\/jats:sc><jats:sub>2<\/jats:sub> were similar in all subjects, but during exercise venous P<jats:sc>O<\/jats:sc><jats:sub>2<\/jats:sub> paradoxically rose in mitochondrial myopathy patients from 27.2 \u00b1 4.0mmHg to 38.2 \u00b1 13.3mmHg, whereas P<jats:sc>O<\/jats:sc><jats:sub>2<\/jats:sub> fell from 27.2 \u00b1 4.2mmHg to 24.2 \u00b1 2.7mmHg in healthy subjects and from 27.4 \u00b1 9.5mmHg to 22.2 \u00b1 5.2mmHg in patient controls. The range of elevated venous P<jats:sc>O<\/jats:sc><jats:sub>2<\/jats:sub> during forearm exercise in mitochondrial myopathy patients (32 to 82mmHg) correlated closely with the severity of oxidative impairment as assessed during cycle exercise. We conclude that measurement of venous P<jats:sc>O<\/jats:sc><jats:sub>2<\/jats:sub> during aerobic forearm exercise provides an easily performed screening test that sensitively detects impaired O<jats:sub>2<\/jats:sub> use and accurately assesses the severity of oxidative impairment in patients with mitochondrial myopathy and exercise intolerance.<\/jats:p>","DOI":"10.1002\/ana.10027","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T16:30:43Z","timestamp":1030293043000},"page":"38-44","source":"Crossref","is-referenced-by-count":79,"title":["Venous oxygen levels during aerobic forearm exercise: An index of impaired oxidative metabolism in mitochondrial myopathy"],"prefix":"10.1002","volume":"51","author":[{"given":"Tanja","family":"Taivassalo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Abbott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phil","family":"Wyrick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald G.","family":"Haller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,12,31]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(200008)48:2<188::AID-ANA8>3.0.CO;2-P"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-2728(98)00113-3"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/109.5.915"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/118.2.339"},{"key":"e_1_2_6_6_2","series-title":"Myology","first-page":"807","author":"Haller RG","year":"1994"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410360603"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.27.5.361"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114135"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115422"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.48.5.1238"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410360606"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.49.3.837"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1969.tb07314.x"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0496-410"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199909303411404"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(199906)45:6<820::AID-ANA22>3.0.CO;2-W"},{"key":"e_1_2_6_18_2","unstructured":"AnitoriRP QuanF BuistNRM et al.A novel mutation in the mitochondrial tRNATrp gene in a sporadic case of mitochondrial myopathy. Presented at the Fourth European Meeting on Mitochondrial Pathology Cambridge UK 1999:73."},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.5.644"},{"key":"e_1_2_6_20_2","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1152\/jappl.1991.70.3.1201","article-title":"Altered high energy phosphate metabolism during exercise in muscle phosphofructokinase deficiency","volume":"70","author":"Bertocci LA","year":"1991","journal-title":"J Appl Physiol"},{"key":"e_1_2_6_21_2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1148\/radiology.143.1.7063747","article-title":"The meaning and use of the area under a receiver operating characteristic (ROC) curve","volume":"148","author":"Hanley JA","year":"1982","journal-title":"Radiology"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.2307\/2531595"},{"key":"e_1_2_6_23_2","series-title":"Energy metabolism of human muscle","author":"Keul J","year":"1972"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2000.88.1.315"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.1990.tb00191.x"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116882"},{"key":"e_1_2_6_27_2","first-page":"263","volume-title":"Exercise and circulation in health and disease","author":"Haller RG","year":"1999"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.1050"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.10027","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.10027","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T12:26:26Z","timestamp":1697027186000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.10027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,12,31]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,1]]}},"alternative-id":["10.1002\/ana.10027"],"URL":"https:\/\/doi.org\/10.1002\/ana.10027","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,12,31]]}}}