{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:01:42Z","timestamp":1791255702212,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2002,2,27]],"date-time":"2002-02-27T00:00:00Z","timestamp":1014768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2002,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Caspase 1 plays a pivotal role in generating mature cytokine interleukin\u20101\u03b2. Interleukin\u20101\u03b2 is implicated as a mediator of pneumococcal meningitis, both in experimental models and in humans. We demonstrated here that (1) Caspase 1 mRNA and protein expression is upregulated in the brain during experimental pneumococcal meningitis, and (2) Caspase 1 levels are elevated in the cerebrospinal fluid of patients with acute bacterial meningitis. The upregulation\/activation of Caspase 1 was associated with increased levels of interleukin\u20101\u03b2. Depletion of the Caspase 1 gene and pharmacologic blockade of Caspase 1 significantly attenuated the meningitis\u2010induced increase in interleukin\u20101\u03b2. This was paralleled by a significantly diminished inflammatory host response to pneumococci. The antiinflammatory effect of Caspase 1 depletion or blockade was associated with a marked reduction of meningitis\u2010induced intracranial complications, thus leading to an improved clinical status. In humans, cerebrospinal fluid Caspase 1 levels correlated with the clinical outcome. Thus, pharmacologic inhibition may provide an efficient adjuvant therapeutic strategy in this disease.<\/jats:p>","DOI":"10.1002\/ana.10103","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T23:10:52Z","timestamp":1030317052000},"page":"319-329","source":"Crossref","is-referenced-by-count":73,"title":["Role of Caspase\u20101 in experimental pneumococcal meningitis: Evidence from pharmacologic Caspase inhibition and Caspase\u20101\u2010deficient 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