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To our knowledge, it is the first mutation to be described in exon 11 of <jats:italic>tau<\/jats:italic>. The proband died at age 53 years, after a disease duration of 15 years, and autopsy revealed a neuropathological picture similar to Pick's disease. Recombinant tau protein with the S320F mutation showed a greatly reduced ability to promote microtubule assembly.<\/jats:p>","DOI":"10.1002\/ana.10140","type":"journal-article","created":{"date-parts":[[2004,10,28]],"date-time":"2004-10-28T04:44:00Z","timestamp":1098938640000},"page":"373-376","source":"Crossref","is-referenced-by-count":83,"title":["A novel <i>tau<\/i> mutation, S320F, causes a tauopathy with inclusions similar to those in Pick's disease"],"prefix":"10.1002","volume":"51","author":[{"given":"Sonia M.","family":"Rosso","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Van 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