{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T11:45:48Z","timestamp":1761392748510},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2002,5,3]],"date-time":"2002-05-03T00:00:00Z","timestamp":1020384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2002,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hypersensitivity syndrome, a serious systematic reaction to a limited number of drugs, is associated with the reactivation of human herpesvirus 6. A 56\u2010year\u2010old man developed acute limbic encephalitis followed by multiple organ failure during the course of toxic dermatitis induced by aromatic anticonvulsants. The clinical features of skin eruptions, high fever, eosinophilia, and atypical lymphocytosis were compatible with drug hypersensitivity syndrome. The patient showed seroconversion for human herpesvirus 6, and polymerase chain reaction detected human herpesvirus 6 DNA in the cerebrospinal fluid. To our knowledge, this is the first report of human herpesvirus 6 encephalitis associated with hypersensitivity syndrome.<\/jats:p>","DOI":"10.1002\/ana.10194","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T23:29:46Z","timestamp":1030318186000},"page":"771-774","source":"Crossref","is-referenced-by-count":58,"title":["Human herpesvirus 6 encephalitis associated with hypersensitivity syndrome"],"prefix":"10.1002","volume":"51","author":[{"given":"Yasuhiro","family":"Fujino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Nakajima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirosato","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiko","family":"Kusuhara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuo","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,5,3]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.29.11.1480"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1997.tb03795.x"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.134.9.1108"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.134.9.1113"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1999.tb06105.x"},{"key":"e_1_2_4_7_2","first-page":"301","article-title":"Association of human herpesvirus 6 infection with drug reaction with eosinophilia and systemic symptoms","volume":"137","author":"Descamps V","year":"2001","journal-title":"Arch Dermatol"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0923-1811(99)00086-9"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199405123301905"},{"key":"e_1_2_4_10_2","first-page":"69","article-title":"Active human herpesvirus (HHV\u20106) infection of the central nervous system in patients with AIDS","volume":"9","author":"Knox KK","year":"1995","journal-title":"J Acquir Immune Defic Syndr Hum Retrovirol"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1998.tb01718.x"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702065"},{"key":"e_1_2_4_13_2","first-page":"94","article-title":"Fatal herpesvirus\u20106 encephalitis in a recipient of a T\u2010cell\u2010depleted peripheral blood stem cell transplant from a 3\u2010loci mismatched related donor","volume":"85","author":"Tiacci E","year":"2000","journal-title":"Haematologica"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200006270-00002"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/169.4.943"},{"key":"e_1_2_4_16_2","doi-asserted-by":"publisher","DOI":"10.1086\/515142"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.10194","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.10194","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T23:02:43Z","timestamp":1695855763000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.10194"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,5,3]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2002,6]]}},"alternative-id":["10.1002\/ana.10194"],"URL":"https:\/\/doi.org\/10.1002\/ana.10194","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,5,3]]}}}