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In 9 patients without orthostatic hypotension, 6\u2010[<jats:sup>18<\/jats:sup>F]fluorodopamine positron emission tomography scanning was repeated after a mean of 2 years from the first scan. 6\u2010[<jats:sup>18<\/jats:sup>F]fluorodopamine\u2010derived radioactivity was less in the second scan than in the first scan, by 31% in the left ventricular free wall and 16% in the septum. In Parkinson's disease, loss of cardiac sympathetic denervation progresses in a pattern of loss suggesting a dying\u2010back mechanism.<\/jats:p>","DOI":"10.1002\/ana.10236","type":"journal-article","created":{"date-parts":[[2002,10,6]],"date-time":"2002-10-06T11:53:08Z","timestamp":1033905188000},"page":"220-223","source":"Crossref","is-referenced-by-count":81,"title":["Progressive loss of cardiac sympathetic innervation in Parkinson's disease"],"prefix":"10.1002","volume":"52","author":[{"given":"Sheng\u2010Ting","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raghuveer","family":"Dendi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney","family":"Holmes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Goldstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,7,23]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1998.tb05958.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.5.1020"},{"key":"e_1_2_6_4_2","first-page":"71","article-title":"Cardiac sympathetic denervation from the early stage of Parkinson's disease: clinical and experimental studies with radiolabeled MIBG","volume":"41","author":"Takatsu H","year":"2000","journal-title":"J Nucl Med"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.284.1.39"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.67.2.189"},{"key":"e_1_2_6_7_2","first-page":"476","article-title":"Iodine 123\u2010labeled meta\u2010iodobenzylguanidine myocardial scintigraphy in the cases of idiopathic Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy","volume":"37","author":"Yoshita M","year":"1997","journal-title":"Rinsho Shinkeigaku"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(97)00278-5"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(00)00279-3"},{"key":"e_1_2_6_10_2","first-page":"202","article-title":"Total defect of metaiodobenzylguanidine (MIBG) imaging on heart in Parkinson's disease: assessment of cardiac sympathetic denervation","volume":"55","author":"Satoh A","year":"1997","journal-title":"Nippon Rinsho"},{"key":"e_1_2_6_11_2","first-page":"371","article-title":"Loss of 123I\u2010MIBG uptake by the heart in Parkinson's disease: assessment of cardiac sympathetic denervation and diagnostic value","volume":"40","author":"Satoh A","year":"1999","journal-title":"J Nucl Med"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002590050548"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002590050544"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-133-5-200009050-00009"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(93)90786-Z"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410440703"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.10236","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.10236","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T04:10:36Z","timestamp":1696997436000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.10236"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,7,23]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2002,8]]}},"alternative-id":["10.1002\/ana.10236"],"URL":"https:\/\/doi.org\/10.1002\/ana.10236","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,7,23]]}}}