{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:33:53Z","timestamp":1791117233906,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2002,7,22]],"date-time":"2002-07-22T00:00:00Z","timestamp":1027296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2002,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>PrP<jats:sup>Sc<\/jats:sup>, the only identified component of the prion, is an aberrant isoform of PrP<jats:sup>C<\/jats:sup>, a glycoprotein of unknown function. In this study, it was shown that valproic acid, a widely used antiepileptic drug, can cause an increase of several orders of magnitude in the accumulation of PrP<jats:sup>C<\/jats:sup> in normal neuroblastoma cells (N2a), and of both PrP isoforms in scrapie infected neuroblastoma cells (ScN2a). Although preliminary results indicate that valproic acid administration to hamsters inoculated with prions had no significant effect on disease incubation time, it is suggested that administration of valproic acid to humans at risk of developing Creutzfeldt\u2010Jakob disease should be evaluated with caution.<\/jats:p>","DOI":"10.1002\/ana.10298","type":"journal-article","created":{"date-parts":[[2002,10,9]],"date-time":"2002-10-09T04:02:01Z","timestamp":1034136121000},"page":"416-420","source":"Crossref","is-referenced-by-count":9,"title":["Valproic acid treatment results in increased accumulation of prion proteins"],"prefix":"10.1002","volume":"52","author":[{"given":"Gideon M.","family":"Shaked","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roni","family":"Engelstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inbal","family":"Avraham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Rosenmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Gabizon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,7,22]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20025"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/37783"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1995.2384"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.33.19197"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.62.5.1558-1564.1988"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.63.1.175-181.1989"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.110.3.743"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.10.6324"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.30.20763"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-197714020-00004"},{"key":"e_1_2_6_12_2","unstructured":"1989 Raven Press New York R Farriello MC Smith R Levy RMB Meldrum JK Penry FE Dreifuss Valproate mechanisms of action in antiepileptic drugs 567 576"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(81)90323-3"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1969.tb08975.x"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1995.tb05996.x"},{"key":"e_1_2_6_16_2","first-page":"83","article-title":"Membrane\u2010disordering potency and anticonvulsant action of valproic acid and other short\u2010chain fatty acids","volume":"26","author":"Perlman BJ","year":"1984","journal-title":"Mol Pharmacol"},{"key":"e_1_2_6_17_2","first-page":"1100","article-title":"The comparative effects of sodium valproate, sodium octanoate, and sodium valerate on spin labeled synaptosomal plasma membranes from mouse brain","volume":"39","author":"Lyon RC","year":"1980","journal-title":"Fed Proc"},{"key":"e_1_2_6_18_2","first-page":"270","article-title":"Effects of sodium valproate on mitochondrial membranes: electron paramagnetic resonance and transmembrane protein movement studies","volume":"30","author":"Rumbach L","year":"1986","journal-title":"Mol Pharmacol"},{"key":"e_1_2_6_19_2","first-page":"583","article-title":"The membrane actions of anesthetics and tranquilizers","volume":"24","author":"Seeman P","year":"1972","journal-title":"Pharmacol Rev"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0082(82)90010-7"},{"key":"e_1_2_6_21_2","first-page":"20","article-title":"Valproic acid: metabolite concentrations in plasma and brain, anticonvulsant activity, and effects on GABA metabolism during subacute treatment in mice","volume":"257","author":"Loscher W","year":"1982","journal-title":"Arch Int Pharmacodyn Ther"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1993.5"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1995.64052256.x"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.25.17981"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.6.3484"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(99)01316-2"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.110.6.2117"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(82)90471-3"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2005.07.004"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/370295a0"},{"key":"e_1_2_6_31_2","volume-title":"Applied pharmacokinetics","author":"Evans WE"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.1997.tb04301.x"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.10298","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.10298","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T12:42:40Z","timestamp":1700311360000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.10298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,7,22]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2002,10]]}},"alternative-id":["10.1002\/ana.10298"],"URL":"https:\/\/doi.org\/10.1002\/ana.10298","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,7,22]]}}}