{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:38:43Z","timestamp":1791189523260,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2002,8,19]],"date-time":"2002-08-19T00:00:00Z","timestamp":1029715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2002,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Alois Alzheimer evaluated five cases of Alzheimer's disease in the early 20th century. We focused on the family of \u201cJohann F.,\u201d Alzheimer's second patient, who died in October 1910 at age 57 years, and whose brain pathology is typical of a subgroup of Alzheimer's disease, the so\u2010called \u201cplaque\u2010only type.\u201d It was perhaps Emil Kraepelin's personal knowledge of this patient and the histological data of the other four cases that influenced Kraepelin to coin the term <jats:italic>Alzheimer's disease<\/jats:italic>. The church archive in Passau has a genealogical database drawn from sacramental registers dating from approximately 1580 to 1900. The genealogical data of the \u201cJohann F.\u201d family, which comes from villages in Lower Bavaria, extends as far back as 1670. We found documentation starting around 1830 about cause of death in the church records, which shows a familial predisposition to dementia. Affected family members include the mother, maternal grandfather, maternal great\u2010aunt, maternal great\u2010grandfather as well as three of Johann F.'s eight siblings. The offspring (children and grandchildren) of these affected siblings also were affected by mental illness. We conclude that \u201cJohann F.\u201d represents the index case of a family with a predisposition to presenile dementia with variable age of onset (30s to 60s).<\/jats:p>","DOI":"10.1002\/ana.10309","type":"journal-article","created":{"date-parts":[[2002,10,9]],"date-time":"2002-10-09T04:02:01Z","timestamp":1034136121000},"page":"520-523","source":"Crossref","is-referenced-by-count":29,"title":["Alzheimer's second patient: Johann F. and his family"],"prefix":"10.1002","volume":"52","author":[{"given":"Hans H.","family":"Kl\u00fcnemann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Fronh\u00f6fer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert","family":"Wurster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Ibach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmfried E.","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,8,19]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"146","article-title":"\u00dcber eine eigenartige Erkrankung der Hirnrinde","volume":"64","author":"Alzheimer A","year":"1907","journal-title":"Allgem Z Psychiatr Psych\u2010Gerich Med"},{"key":"e_1_2_6_3_2","first-page":"297","volume-title":"Histologische und Histopathologische Arbeiten \u00fcber die Grosshirnrinde","author":"Perusini G","year":"1908"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)10203-8"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s100480050033"},{"key":"e_1_2_6_6_2","volume-title":"Alzheimer. 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