{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T23:54:44Z","timestamp":1784678084180,"version":"3.55.0"},"reference-count":87,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2002,11,12]],"date-time":"2002-11-12T00:00:00Z","timestamp":1037059200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2002,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Experimental studies demonstrate an alkaline shift in brain intracellular pH (pH<jats:sub>i<\/jats:sub>) after hypoxia\u2010ischemia (HI). In infants with neonatal encephalopathy after HI, our aims were to assess (1) brain pH<jats:sub>i<\/jats:sub> during the first 2 weeks after birth in infants categorized according to magnetic resonance imaging (MRI) during the first 2 weeks after birth and at more than 3 months of age, and neurodevelopmental outcome at 1 year; (2) the relationship between brain pH<jats:sub>i<\/jats:sub> and lactate\/creatine; and (3) duration of alkaline brain pH<jats:sub>i<\/jats:sub>. Seventy\u2010eight term infants with neonatal encephalopathy were studied using MR techniques. One hundred and fifty\u2010one studies were performed throughout the first year including 56 studies of 50 infants during the first 2 weeks after birth. pH<jats:sub>i<\/jats:sub> was calculated using phosphorus\u201031 MR spectroscopy and lactate\/creatine was measured using proton MRS. The mean (standard deviation [SD]) brain pH<jats:sub>i<\/jats:sub> during the first 2 weeks after birth in infants with severely abnormal versus normal MRI was 7.24 (SD, 0.17) versus 7.04 (SD, 0.05; <jats:italic>p<\/jats:italic> &lt; 0.001); in infants who subsequently developed cerebral atrophy versus those who did not: 7.23 (SD, 0.17) versus 7.06 (SD, 0.06; <jats:italic>p<\/jats:italic> &lt; 0.05); in infants who died or had a severe neurodevelopmental impairment versus normal outcome: 7.28 (SD, 0.15) versus 7.11 (SD, 0.09; <jats:italic>p<\/jats:italic> &lt; 0.05). Brain alkalosis was associated with increased brain lactate\/creatine (<jats:italic>p<\/jats:italic> &lt; 0.001). pH<jats:sub>i<\/jats:sub> remained more alkaline in the severe outcome group up to 20 weeks after birth (<jats:italic>p<\/jats:italic> &lt; 0.05). Ann Neurol 2002;52:000\u2013000<\/jats:p>","DOI":"10.1002\/ana.10365","type":"journal-article","created":{"date-parts":[[2002,12,2]],"date-time":"2002-12-02T13:54:44Z","timestamp":1038837284000},"page":"732-742","source":"Crossref","is-referenced-by-count":73,"title":["Brain alkaline intracellular pH after neonatal encephalopathy"],"prefix":"10.1002","volume":"52","author":[{"given":"Nicola J.","family":"Robertson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances M.","family":"Cowan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. Jane","family":"Cox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. David","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,11,12]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1981.61.2.296"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(08)63257-4"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1983.13"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/345347a0"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.23.12.1817"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199803300-00021"},{"key":"e_1_2_6_8_2","first-page":"1428","article-title":"Brain acidosis induced by hypercarbic ventilation attenuates focal ischaemic injury","volume":"267","author":"Simon RP","year":"1993","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200106000-00015"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1996.67062379.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"crossref","first-page":"7276","DOI":"10.1016\/S0021-9258(19)43389-9","article-title":"Determination of intracellular pH by 31P MR","volume":"248","author":"Moon RB","year":"1973","journal-title":"J Biol Chem"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.21.3.463"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1990.142"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1089\/08977150151070838"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1992.104"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.185.2.1410369"},{"key":"e_1_2_6_17_2","first-page":"21","article-title":"Pathophysiological correlates of cerebral ischaemia and the significance of cellular acid base shifts","volume":"5","author":"Welch KM","year":"1990","journal-title":"Funct Neurol"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198905000-00004"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199611000-00015"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199412000-00003"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4400353"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1992.tb11432.x"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/00008480-199810060-00006"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)91906-2"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.39.5.709"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)90088-0"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)90539-7"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1976.00500100030012"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199909000-00007"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200010000-00006"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0730-725X(94)00104-B"},{"key":"e_1_2_6_32_2","first-page":"77","article-title":"Bioenergetics of intact human muscle. A 31P NMR study","volume":"1","author":"Taylor DJ","year":"1983","journal-title":"Mol Biol Med"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.102.2.323"},{"key":"e_1_2_6_34_2","volume-title":"The abilities of babies","author":"Griffiths R","year":"1996"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(99)70016-8"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.111325"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.174.2.2296651"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1492(199710)10:7<309::AID-NBM484>3.0.CO;2-0"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198905000-00003"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199404000-00009"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.176.2.2164237"},{"key":"e_1_2_6_42_2","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1080\/01616412.1991.11739962","article-title":"Quantitation of high energy phosphate compounds and metabolic significance in the developing dog brain","volume":"13","author":"Nioka S","year":"1991","journal-title":"Neurol Res"},{"key":"e_1_2_6_43_2","first-page":"42","volume-title":"NMR and its application to living systems","author":"Gadian DG","year":"1995"},{"key":"e_1_2_6_44_2","first-page":"599","volume-title":"Basic neurochemistry","author":"Siegel GJ","year":"1989"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7742(08)60035-5"},{"key":"e_1_2_6_46_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199601000-00007"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-979751"},{"key":"e_1_2_6_48_2","doi-asserted-by":"publisher","DOI":"10.1136\/fn.75.3.F145"},{"key":"e_1_2_6_49_2","first-page":"143","article-title":"Prediction of neuro\u2010motor outcome in perinatal asphyxia: evaluation of MR scoring systems","volume":"19","author":"Barkovich AJ","year":"1998","journal-title":"AJNR"},{"key":"e_1_2_6_50_2","doi-asserted-by":"publisher","DOI":"10.1159\/000046140"},{"key":"e_1_2_6_51_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.1999.tb00213.x"},{"key":"e_1_2_6_52_2","doi-asserted-by":"publisher","DOI":"10.1097\/00008480-199704000-00002"},{"key":"e_1_2_6_53_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03550030047032"},{"key":"e_1_2_6_54_2","first-page":"1537","article-title":"Antepartum risk factors for NE: the Western Australian case\u2010control study","volume":"317","author":"Badawi N","year":"1998","journal-title":"BMJ"},{"key":"e_1_2_6_55_2","doi-asserted-by":"publisher","DOI":"10.1136\/fn.81.1.F19"},{"key":"e_1_2_6_56_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.218.3.r01fe47825"},{"key":"e_1_2_6_57_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-0333-6_36"},{"key":"e_1_2_6_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(91)91887-I"},{"key":"e_1_2_6_59_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1993.265.1.C129"},{"key":"e_1_2_6_60_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.5.2.2004664"},{"key":"e_1_2_6_61_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006827601337"},{"key":"e_1_2_6_62_2","first-page":"211","volume-title":"pH and brain function","author":"Bevensee MO","year":"1998"},{"key":"e_1_2_6_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4157(89)90004-X"},{"key":"e_1_2_6_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(87)91594-0"},{"key":"e_1_2_6_65_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.6.2424"},{"key":"e_1_2_6_66_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01869680"},{"key":"e_1_2_6_67_2","doi-asserted-by":"crossref","first-page":"13811","DOI":"10.1016\/S0021-9258(17)36720-0","article-title":"Cytokines and HIV envelope glycoprotein GP 120 stimulate Na+\/H+ exchange in astrocytes","volume":"269","author":"Benos DJ","year":"1994","journal-title":"J Biol Chem"},{"key":"e_1_2_6_68_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1984.246.4.R409"},{"key":"e_1_2_6_69_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199506000-00017"},{"key":"e_1_2_6_70_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1989.sp017567"},{"key":"e_1_2_6_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0082(95)00039-9"},{"key":"e_1_2_6_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(96)00004-8"},{"key":"e_1_2_6_73_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.11-08-02489.1991"},{"key":"e_1_2_6_74_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.09-06-02011.1989"},{"key":"e_1_2_6_75_2","first-page":"249","volume-title":"Cerebrovascular disease: pathology, diagnosis and management","author":"Kraig RP","year":"1998"},{"key":"e_1_2_6_76_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199703000-00001"},{"key":"e_1_2_6_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(96)00578-1"},{"key":"e_1_2_6_78_2","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(200004)47:4<485::AID-ANA12>3.0.CO;2-8"},{"key":"e_1_2_6_79_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410080310"},{"key":"e_1_2_6_80_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1988.137"},{"key":"e_1_2_6_81_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(95)00516-S"},{"key":"e_1_2_6_82_2","doi-asserted-by":"publisher","DOI":"10.1159\/000017330"},{"key":"e_1_2_6_83_2","doi-asserted-by":"publisher","DOI":"10.1139\/bcb-76-2-3-503"},{"key":"e_1_2_6_84_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199706000-00001"},{"key":"e_1_2_6_85_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910210215"},{"key":"e_1_2_6_86_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1982.242.1.C87"},{"key":"e_1_2_6_87_2","doi-asserted-by":"publisher","DOI":"10.1159\/000017324"},{"key":"e_1_2_6_88_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.22.10625"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.10365","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.10365","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T04:39:56Z","timestamp":1696999196000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.10365"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,11,12]]},"references-count":87,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2002,12]]}},"alternative-id":["10.1002\/ana.10365"],"URL":"https:\/\/doi.org\/10.1002\/ana.10365","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,11,12]]}}}