{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T06:04:06Z","timestamp":1772172246148,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2002,11,4]],"date-time":"2002-11-04T00:00:00Z","timestamp":1036368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2002,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Recently, a single nucleotide polymorphism that results in an amino acid change (Q7R) was identified in a previously undescribed gene, named <jats:italic>saitohin<\/jats:italic>, nested within the <jats:italic>tau<\/jats:italic> gene. We analyzed the distribution of this polymorphism in 499 patients with Alzheimer's disease, 91 patients with frontotemporal dementia, and 402 controls. This polymorphism was in complete disequilibrium with the well\u2010defined extended <jats:italic>tau<\/jats:italic> haplotype. We failed to replicate the association between the RR genotype and late\u2010onset Alzheimer's disease, but we found a trend toward an association between the QQ genotype and frontotemporal dementia. Thus, the <jats:italic>saitohin<\/jats:italic> Q allele, which is a novel determinant of the <jats:italic>tau H1<\/jats:italic> haplotypes, might represent a causative factor involved in the determinism of several tauopathies.<\/jats:p>","DOI":"10.1002\/ana.10384","type":"journal-article","created":{"date-parts":[[2002,12,2]],"date-time":"2002-12-02T13:54:44Z","timestamp":1038837284000},"page":"829-832","source":"Crossref","is-referenced-by-count":29,"title":["Is the <i>Saitohin<\/i> gene involved in neurodegenerative 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