{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T17:22:22Z","timestamp":1791134542069,"version":"4.1.0"},"reference-count":178,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2003,1,2]],"date-time":"2003-01-02T00:00:00Z","timestamp":1041465600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2003,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Narcolepsy is a common cause of chronic sleepiness distinguished by intrusions into wakefulness of physiological aspects of rapid eye movement sleep such as cataplexy and hallucinations. Recent advances provide compelling evidence that narcolepsy may be a neurodegenerative or autoimmune disorder resulting in a loss of hypothalamic neurons containing the neuropeptide orexin (also known as hypocretin). Because orexin promotes wakefulness and inhibits rapid eye movement sleep, its absence may permit inappropriate transitions between wakefulness and sleep. These discoveries have considerably improved our understanding of the neurobiology of sleep and should foster the development of rational treatments for a variety of sleep disorders. Ann Neurol 2003<\/jats:p>","DOI":"10.1002\/ana.10444","type":"journal-article","created":{"date-parts":[[2003,1,30]],"date-time":"2003-01-30T14:05:52Z","timestamp":1043935552000},"page":"154-166","source":"Crossref","is-referenced-by-count":206,"title":["The neurobiology, diagnosis, and treatment of narcolepsy"],"prefix":"10.1002","volume":"53","author":[{"given":"Thomas E.","family":"Scammell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,1,23]]},"reference":[{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005053-193003000-00001"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/25.1.27"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/25.2.197"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(88)90145-9"},{"key":"e_1_2_12_6_2","first-page":"159","article-title":"Impaired circadian waking arousal in narcolepsy\u2010cataplexy","volume":"1","author":"Broughton R","year":"1998","journal-title":"Sleep Res Online"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2869.2000.00217.x"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(94)90019-1"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.46.2.393"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)92992-3"},{"key":"e_1_2_12_11_2","first-page":"65","article-title":"Clinical aspects and features of cataplexy","volume":"67","author":"Guilleminault C","year":"1995","journal-title":"Adv Neurol"},{"key":"e_1_2_12_12_2","first-page":"77","article-title":"Validation of a cataplexy questionnaire in 983 sleep\u2010disorders patients","volume":"22","author":"Anic\u2010Labat S","year":"1999","journal-title":"Sleep"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-2457(00)00412-0"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)80023-3"},{"key":"e_1_2_12_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-2457(00)00306-0"},{"key":"e_1_2_12_16_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1925546"},{"key":"e_1_2_12_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/24.5.603"},{"key":"e_1_2_12_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2869.1993.tb00078.x"},{"key":"e_1_2_12_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410320103"},{"key":"e_1_2_12_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/9.4.519"},{"key":"e_1_2_12_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004691-199201000-00007"},{"key":"e_1_2_12_22_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.1_Part_1.55"},{"key":"e_1_2_12_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(79)90149-4"},{"key":"e_1_2_12_24_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.2.9905071"},{"key":"e_1_2_12_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-2457(01)00483-7"},{"key":"e_1_2_12_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410120313"},{"key":"e_1_2_12_27_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.46.5.1258"},{"key":"e_1_2_12_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/120.8.1423"},{"key":"e_1_2_12_29_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.10.1372"},{"key":"e_1_2_12_30_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.39.11.1505"},{"key":"e_1_2_12_31_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.3.539"},{"key":"e_1_2_12_32_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.12.1775"},{"key":"e_1_2_12_33_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.12.1751"},{"key":"e_1_2_12_34_2","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1093\/sleep\/18.3.202","article-title":"Narcolepsy associated with arteriovenous malformation of the diencephalon","volume":"18","author":"Clavelou P","year":"1995","journal-title":"Sleep"},{"key":"e_1_2_12_35_2","volume-title":"Encephalitis lethargica: its sequela and treatment","author":"von Economo C","year":"1931"},{"key":"e_1_2_12_36_2","first-page":"1044","article-title":"Narkolepsie nach Enzephalitis Lethargica","volume":"37","author":"Stiefler G","year":"1924","journal-title":"Wien Klin"},{"key":"e_1_2_12_37_2","first-page":"257","article-title":"Idiopathic narcolepsy: a disease sui generis, with remarks on the mechanism of sleep","volume":"49","author":"Adie J","year":"1926","journal-title":"Brain Res"},{"key":"e_1_2_12_38_2","first-page":"751","article-title":"Narcolepsie en apparence idiopathique, en r\u00e9alit\u00e9 sequelle d'enc\u00e9phalite frustre","volume":"1","author":"Lhermitte J","year":"1927","journal-title":"Rev Neurol (Paris)"},{"key":"e_1_2_12_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.1288"},{"key":"e_1_2_12_40_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.9.2190"},{"key":"e_1_2_12_41_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.11.2189"},{"key":"e_1_2_12_42_2","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1017\/S0317167100039202","article-title":"Narcolepsy secondary to fourth ventricular subependymoma","volume":"23","author":"Ma TK","year":"1996","journal-title":"Can J Neurol Sci"},{"key":"e_1_2_12_43_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410190516"},{"key":"e_1_2_12_44_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.33.12.1584"},{"key":"e_1_2_12_45_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1963.tb05329.x"},{"key":"e_1_2_12_46_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.30.1.105"},{"key":"e_1_2_12_47_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.41.3.447"},{"key":"e_1_2_12_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0987-7053(01)00282-9"},{"key":"e_1_2_12_49_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410350612"},{"key":"e_1_2_12_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)91977-6"},{"key":"e_1_2_12_51_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.2_Suppl_1.S16"},{"key":"e_1_2_12_52_2","first-page":"187","volume-title":"Sleep\/wake disorders: natural history, epidemiology, and long\u2010term evolution","author":"Honda Y","year":"1983"},{"key":"e_1_2_12_53_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.37.12.1858"},{"key":"e_1_2_12_54_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.48.6.1550"},{"key":"e_1_2_12_55_2","doi-asserted-by":"publisher","DOI":"10.1086\/318799"},{"key":"e_1_2_12_56_2","first-page":"347","article-title":"Nocturnal sleep and daytime sleepiness in normal subjects with HLA\u2010DQB1*0602","volume":"22","author":"Mignot E","year":"1999","journal-title":"Sleep"},{"key":"e_1_2_12_57_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0039.2001.057003230.x"},{"key":"e_1_2_12_58_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0039.1999.540204.x"},{"key":"e_1_2_12_59_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0039.2000.560508.x"},{"key":"e_1_2_12_60_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.4.1149"},{"key":"e_1_2_12_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(02)02262-X"},{"key":"e_1_2_12_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(00)02002-6"},{"key":"e_1_2_12_63_2","first-page":"145","volume-title":"Principles and practice of sleep medicine","author":"Jones B","year":"1994"},{"key":"e_1_2_12_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(50)90086-1"},{"key":"e_1_2_12_65_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1988.68.3.649"},{"key":"e_1_2_12_66_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8235588"},{"key":"e_1_2_12_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(95)01431-4"},{"key":"e_1_2_12_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(08)63830-3"},{"key":"e_1_2_12_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(76)90480-7"},{"key":"e_1_2_12_70_2","first-page":"195","article-title":"Specific neurons for wakefulness in the posterior hypothalamus in the cat","volume":"298","author":"Vanni\u2010Mercier G","year":"1984","journal-title":"C R Acad Sci III"},{"key":"e_1_2_12_71_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.3.341"},{"key":"e_1_2_12_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(96)00070-6"},{"key":"e_1_2_12_73_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-05-01787.2001"},{"key":"e_1_2_12_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4886(84)90105-5"},{"key":"e_1_2_12_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(83)91101-0"},{"key":"e_1_2_12_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(73)90830-5"},{"key":"e_1_2_12_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(01)03402-3"},{"key":"e_1_2_12_78_2","first-page":"A290","article-title":"Identification of wake\u2010active dopaminergic neurons in the ventral periaqueductal gray (PAG)","volume":"25","author":"Lu J","year":"2002","journal-title":"Sleep"},{"key":"e_1_2_12_79_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1135627"},{"key":"e_1_2_12_80_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.13-09-03878.1993"},{"key":"e_1_2_12_81_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(94)90599-1"},{"key":"e_1_2_12_82_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-4669-3"},{"key":"e_1_2_12_83_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(98)00429-1"},{"key":"e_1_2_12_84_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.271.5246.216"},{"key":"e_1_2_12_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(98)00631-3"},{"key":"e_1_2_12_86_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-10-03830.2000"},{"key":"e_1_2_12_87_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-12-04705.1998"},{"key":"e_1_2_12_88_2","doi-asserted-by":"publisher","DOI":"10.1038\/35010109"},{"key":"e_1_2_12_89_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.24.1.429"},{"key":"e_1_2_12_90_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80949-6"},{"key":"e_1_2_12_91_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.1.322"},{"key":"e_1_2_12_92_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19981228)402:4<442::AID-CNE2>3.0.CO;2-R"},{"key":"e_1_2_12_93_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-23-09996.1998"},{"key":"e_1_2_12_94_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81973-X"},{"key":"e_1_2_12_95_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.1190"},{"key":"e_1_2_12_96_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-05-01656.2001"},{"key":"e_1_2_12_97_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0953-816x.2001.01725.x"},{"key":"e_1_2_12_98_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2001.012888"},{"key":"e_1_2_12_99_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.19.10911"},{"key":"e_1_2_12_100_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0953-816x.2001.01777.x"},{"key":"e_1_2_12_101_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.6318"},{"key":"e_1_2_12_102_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-23-09273.2001"},{"key":"e_1_2_12_103_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(00)00178-7"},{"key":"e_1_2_12_104_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-20-07760.2000"},{"key":"e_1_2_12_105_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.181330998"},{"key":"e_1_2_12_106_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(01)02270-4"},{"key":"e_1_2_12_107_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81965-0"},{"key":"e_1_2_12_108_2","first-page":"A20","article-title":"Behavioral characterization of orexin\u20102 receptor (OX2R) knockout mice","volume":"24","author":"Tokita S","year":"2001","journal-title":"Sleep"},{"key":"e_1_2_12_109_2","first-page":"A22","article-title":"Behavioral and polysomnographic characterization of orexin\u20101 receptor and orexin\u20102 receptor double knockout mice","volume":"24","author":"Kisanuki Y","year":"2001","journal-title":"Sleep"},{"key":"e_1_2_12_110_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00293-8"},{"key":"e_1_2_12_111_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)05582-8"},{"key":"e_1_2_12_112_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.12.2253"},{"key":"e_1_2_12_113_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.1130"},{"key":"e_1_2_12_114_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2869.2002.00284.x"},{"key":"e_1_2_12_115_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.12.1749"},{"key":"e_1_2_12_116_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.59.10.1553"},{"key":"e_1_2_12_117_2","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(200101)49:1<136::AID-ANA25>3.0.CO;2-M"},{"key":"e_1_2_12_118_2","doi-asserted-by":"publisher","DOI":"10.1038\/79690"},{"key":"e_1_2_12_119_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)00058-1"},{"key":"e_1_2_12_120_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.10.1896"},{"key":"e_1_2_12_121_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.10.1893"},{"key":"e_1_2_12_122_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-83387-8_4"},{"key":"e_1_2_12_123_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.48.4.1097"},{"key":"e_1_2_12_124_2","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1093\/sleep\/20.8.630","article-title":"MRI findings in narcolepsy","volume":"20","author":"Bassetti C","year":"1997","journal-title":"Sleep"},{"key":"e_1_2_12_125_2","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1093\/sleep\/24.3.321","article-title":"Childhood narcolepsy in North China","volume":"24","author":"Han F","year":"2001","journal-title":"Sleep"},{"key":"e_1_2_12_126_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.2.577-a"},{"key":"e_1_2_12_127_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(88)90104-3"},{"key":"e_1_2_12_128_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.46.5.1250"},{"key":"e_1_2_12_129_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1990.tb00978.x"},{"key":"e_1_2_12_130_2","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1093\/sleep\/9.1.126","article-title":"Narcolepsy: a neuropathologic study","volume":"9","author":"Erlich SS","year":"1986","journal-title":"Sleep"},{"key":"e_1_2_12_131_2","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(94)90110-4"},{"key":"e_1_2_12_132_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-05-03526.1995"},{"key":"e_1_2_12_133_2","doi-asserted-by":"publisher","DOI":"10.1037\/h0084284"},{"key":"e_1_2_12_134_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(97)00241-4"},{"key":"e_1_2_12_135_2","first-page":"46","article-title":"Melatonin plasma concentration during daytime and nighttime in narcoleptic subjects and controls","volume":"15","author":"Bourgine N","year":"1986","journal-title":"Sleep Res"},{"key":"e_1_2_12_136_2","first-page":"521","volume-title":"Narcolepsy","author":"Weitzman E","year":"1976"},{"key":"e_1_2_12_137_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00836.2001"},{"key":"e_1_2_12_138_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-13-04864.2001"},{"key":"e_1_2_12_139_2","unstructured":"ChouT ScammellT LuJ et al.Excitotoxic lesions of the dorsomedial hypothalamic nucleus markedly attenuate circadian rhythms of sleep and body temperature. Paper presented at: Annual Meeting of the Society for Neuroscience;2000."},{"key":"e_1_2_12_140_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-18-07273.2001"},{"key":"e_1_2_12_141_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.2.748"},{"key":"e_1_2_12_142_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2000.278.3.R692"},{"key":"e_1_2_12_143_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.37.6.1382"},{"key":"e_1_2_12_144_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)74704-8"},{"key":"e_1_2_12_145_2","doi-asserted-by":"publisher","DOI":"10.1159\/000054587"},{"key":"e_1_2_12_146_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004060170057"},{"key":"e_1_2_12_147_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/19.1.75"},{"key":"e_1_2_12_148_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1819.2001.00841.x"},{"key":"e_1_2_12_149_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/16.5.444"},{"key":"e_1_2_12_150_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/24.4.385"},{"key":"e_1_2_12_151_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/17.suppl_8.S103"},{"key":"e_1_2_12_152_2","first-page":"49","article-title":"Increased dopaminergic transmission mediates the wake\u2010promoting effects of CNS stimulants","volume":"1","author":"Nishino S","year":"1998","journal-title":"Sleep Res Online"},{"key":"e_1_2_12_153_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410430115"},{"key":"e_1_2_12_154_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.5.1166"},{"key":"e_1_2_12_155_2","first-page":"493","article-title":"A new alternative in the pharmacologic management of somnolence: a phase III study of modafinil in narcolepsy","volume":"40","author":"Fry J","year":"1996","journal-title":"Ann Neurol"},{"key":"e_1_2_12_156_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1389-9457(00)00031-9"},{"key":"e_1_2_12_157_2","doi-asserted-by":"publisher","DOI":"10.1177\/026988110001400107"},{"key":"e_1_2_12_158_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02247379"},{"key":"e_1_2_12_159_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/17.5.436"},{"key":"e_1_2_12_160_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00176625"},{"key":"e_1_2_12_161_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(96)13212-2"},{"key":"e_1_2_12_162_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-22-08620.2000"},{"key":"e_1_2_12_163_2","unstructured":"MillerM ChatterjeeS AimoneL et al.Novel non\u2010dopaminergic wake promoting and cortical activating agents. Paper presented at: Annual Meeting of the Society for Neuroscience;2001; San Diego."},{"key":"e_1_2_12_164_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/24.3.282"},{"key":"e_1_2_12_165_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.4.707"},{"key":"e_1_2_12_166_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1987.tb09990.x"},{"key":"e_1_2_12_167_2","doi-asserted-by":"publisher","DOI":"10.3109\/15563659709001236"},{"key":"e_1_2_12_168_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(92)90347-7"},{"key":"e_1_2_12_169_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/9.1.285"},{"key":"e_1_2_12_170_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/13.6.479"},{"key":"e_1_2_12_171_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/16.3.216"},{"key":"e_1_2_12_172_2","first-page":"42","article-title":"A randomized, double blind, placebo\u2010controlled multicenter trial comparing the effects of three doses of orally administered sodium oxybate with placebo for the treatment of narcolepsy","volume":"25","author":"Cook H","year":"2002","journal-title":"Sleep"},{"key":"e_1_2_12_173_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200101113440202"},{"key":"e_1_2_12_174_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0644(98)70231-8"},{"key":"e_1_2_12_175_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1987.tb01614.x"},{"key":"e_1_2_12_176_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-83387-8_3"},{"key":"e_1_2_12_177_2","first-page":"1012","article-title":"HLA DQB1*0602 is associated with cataplexy in 509 narcoleptic patients","volume":"20","author":"Mignot E","year":"1997","journal-title":"Sleep"},{"key":"e_1_2_12_178_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(90)90042-Z"},{"key":"e_1_2_12_179_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(01)00316-5"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.10444","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T20:28:39Z","timestamp":1697056119000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.10444"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,1,23]]},"references-count":178,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2003,2]]}},"alternative-id":["10.1002\/ana.10444"],"URL":"https:\/\/doi.org\/10.1002\/ana.10444","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,1,23]]}}}