{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T01:46:17Z","timestamp":1788918377612,"version":"build-2803163510"},"reference-count":49,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2003,4,10]],"date-time":"2003-04-10T00:00:00Z","timestamp":1049932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2003,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Guillain\u2013Barr\u00e9 syndrome (GBS) is an immune\u2010mediated neuropathy, in which leukocytes and humoral components of the immune system proposedly initiate localized inflammation. An important pathogenic role for anti\u2013GM1 ganglioside antibodies has been suggested. Therefore, we evaluated anti\u2010GM1 IgG antibody\u2010induced leukocyte effector functions such as degranulation and phagocytosis using serum of 24 GBS patients. Serum without anti\u2010GM1 antibodies of 9 GBS patients as well as pooled serum from healthy individuals served as controls. Ten out of 15 (67%) of anti\u2010GM1 IgG positive sera were capable of inducing leukocyte degranulation, and 8 out of 15 (53%) of anti\u2010GM1 IgG positive sera were capable of inducing phagocytosis of GM1\u2010coated beads. In all of these sera anti\u2010GM1 antibody titers were \u22651:800. No leukocyte degranulation or phagocytosis was observed in control sera. Leukocyte activation was completely abrogated in the presence of IgG receptor (Fc\u03b3R) blocking antibodies, suggesting a crucial role for leukocyte Fc\u03b3R in GBS pathogenesis. No correlation of antibody titers with the extent of leukocyte activation, or severity of disease was observed. These data document the capacity of anti\u2010GM1 IgG antibodies to activate leukocyte inflammatory functions, and suggest an important role for anti\u2010ganglioside IgG antibodies in the pathogenesis of GBS.<\/jats:p>","DOI":"10.1002\/ana.10503","type":"journal-article","created":{"date-parts":[[2003,4,29]],"date-time":"2003-04-29T10:01:39Z","timestamp":1051610499000},"page":"570-579","source":"Crossref","is-referenced-by-count":27,"title":["Anti\u2013GM1 IgG antibodies induce leukocyte effector functions via Fc\u03b3 receptors"],"prefix":"10.1002","volume":"53","author":[{"given":"Nina M.","family":"van Sorge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard H.","family":"van den Berg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Geleijns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos A.","family":"van Strijp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart C.","family":"Jacobs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter A.","family":"van Doorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John H. 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