{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:04:00Z","timestamp":1791320640611,"version":"4.3.1"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2003,3,6]],"date-time":"2003-03-06T00:00:00Z","timestamp":1046908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2003,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We identified the IgG autoantibody ANNA\u20102 (\u201canti\u2010Ri\u201d) in 34 patients in a 12\u2010year period by immunofluorescence screening of sera from approximately 75,000 patients with subacute neurological disorders that were suspected to be paraneoplastic. Detailed clinical information was available for 28 patients (10 men, 18 women). Cancer was diagnosed in 24 patients (86%); 21 had histologically proven carcinoma (10 lung, 9 breast, 1 cervical, 1 bladder), and 3 had an intrathoracic imaging abnormality. Cancer anteceded neurological symptoms in 4 of 28 patients. Cancer detection frequency increased with continued surveillance. Neurological disorders, in decreasing frequency, were brainstem syndrome (including opsoclonus, myoclonus, or both), cerebellar syndrome, myelopathy, peripheral neuropathy, cranial neuropathy, movement disorder, encephalopathy, Lambert\u2013Eaton syndrome, and seizures. Four patients had laryngospasm and four had jaw opening dystonia (two with neck dystonia). Nine (32%) were wheelchair\u2010bound 1 month after neurological symptom onset. Most improved neurologically after immunomodulatory or tumor\u2010directed therapy. Accompanying autoantibodies, found in 73% of sera, included ANNA\u20101, ANNA\u20103, CRMP\u20105\u2010IgG, P\/Q\u2010type and N\u2010type Ca<jats:sup>2+<\/jats:sup> channel antibodies, and muscle\u2010type acetylcholine receptor antibody. Some neurological accompaniments of ANNA\u20102 may reflect potentially pathogenic humoral or cell\u2010mediated responses to coimmunogenic tumor antigens, for example, Lambert\u2013Eaton syndrome (P\/Q\u2010type Ca<jats:sup>2+<\/jats:sup> channel antibody) and peripheral neuropathy (ANNA\u20101 effector T cells). Ann Neurol 2003<\/jats:p>","DOI":"10.1002\/ana.10518","type":"journal-article","created":{"date-parts":[[2003,4,29]],"date-time":"2003-04-29T10:01:39Z","timestamp":1051610499000},"page":"580-587","source":"Crossref","is-referenced-by-count":276,"title":["Anti\u2010neuronal nuclear autoantibody type 2: Paraneoplastic accompaniments"],"prefix":"10.1002","volume":"53","author":[{"given":"Sean J.","family":"Pittock","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia F.","family":"Lucchinetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanda 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