{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:55:15Z","timestamp":1791176115937,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2003,5,14]],"date-time":"2003-05-14T00:00:00Z","timestamp":1052870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2003,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Autoantibodies have defined two paraneoplastic visual disorders related to small\u2010cell lung carcinoma: retinopathy (\u201cCAR\u201d\u2010IgG [23kDa, recoverin]) and optic neuritis collapsin response\u2010mediated protein 5 (CRMP\u20105\u2010IgG [62kDa]). Among 16 patients with CRMP\u20105\u2010IgG and optic neuritis (aged 52\u201374 years; all smokers, 9 women), we documented coexisting retinitis in 5. None had CAR\u2010IgG. Fifteen had subacute vision loss, swollen optic discs, and field defects. Vascular leakage was evident at and remote from the disc; 5\/5 tested had abnormal electroretinograms. Nine had striking vitreous cells. Vitrectomy showed reactive lymphocytosis (4\/4), predominantly CD4<jats:sup>+<\/jats:sup> (1\/1). Most patients had multifocal neurological accompaniments. Cerebrospinal fluid contained lymphocytes (7\u201032), elevated protein, multiple oligoclonal immunoglobulin bands, and CRMP\u20105\u2010IgG. Three patients superficially resembled Devic's disease at presentation. One autopsied patient had predominantly CD8<jats:sup>+<\/jats:sup> T lymphocytes infiltrating optic nerve and spinal cord. Eleven patients had confirmed small\u2010cell carcinoma; 1 had imaging evidence of lung cancer; 3 had renal or thyroid carcinoma. Full\u2010length CRMP\u20105 protein was identified in normal retina and optic nerve by Western blot analyses. Photoreceptor cells, retinal ganglion cells, and nerve fibers exhibited CRMP\u20105\u2013specific immunoreactivity. In summary, CRMP\u20105\u2010IgG defines a paraneoplastic ophthalmological entity of combined optic neuritis and retinitis with vitreous inflammatory cells. Positive serology obviates the need for vitreous biopsy and expedites the search for cancer. Ann Neurol 2003<\/jats:p>","DOI":"10.1002\/ana.10587","type":"journal-article","created":{"date-parts":[[2003,6,27]],"date-time":"2003-06-27T10:01:20Z","timestamp":1056708080000},"page":"38-50","source":"Crossref","is-referenced-by-count":240,"title":["Paraneoplastic autoimmune optic neuritis with retinitis defined by CRMP\u20105\u2010IgG"],"prefix":"10.1002","volume":"54","author":[{"given":"Shelley A.","family":"Cross","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diva R.","family":"Salomao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph E.","family":"Parisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Kryzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth 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