{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T09:55:52Z","timestamp":1793354152269,"version":"4.5.0"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2003,12,30]],"date-time":"2003-12-30T00:00:00Z","timestamp":1072742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"European Union (EU) Project","award":["TSELAB QLK2-CT-2002-81523"],"award-info":[{"award-number":["TSELAB QLK2-CT-2002-81523"]}]},{"name":"EU Concerted Action PRIONET","award":["QLK2-2000-CT-00837"],"award-info":[{"award-number":["QLK2-2000-CT-00837"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2004,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pathologicalprion protein (PrP<jats:sup>Sc<\/jats:sup>) is the hallmark of prion diseases affecting primarily the central nervous system. Using immunohistochemistry, paraffin\u2010embedded tissue blot, and Western blot, we demonstrated abundant PrP<jats:sup>Sc<\/jats:sup> in the muscle of a patient with sporadic Creutzfeldt\u2013Jakob disease and inclusion body myositis. Extraneural PrP<jats:sup>C<\/jats:sup>\u2010PrP<jats:sup>Sc<\/jats:sup> conversion in Creutzfeldt\u2013Jakob disease appears to become prominent when PrP<jats:sup>C<\/jats:sup> is abundantly available as substrate, as in inclusion body myositis muscle.<\/jats:p>","DOI":"10.1002\/ana.10813","type":"journal-article","created":{"date-parts":[[2003,12,31]],"date-time":"2003-12-31T09:34:51Z","timestamp":1072863291000},"page":"121-125","source":"Crossref","is-referenced-by-count":44,"title":["Creutzfeldt\u2013Jakob disease and inclusion body myositis: Abundant disease\u2010associated prion protein in muscle"],"prefix":"10.1002","volume":"55","author":[{"given":"Gabor G.","family":"Kovacs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Lindeck\u2010Pozza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Chimelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abelardo Q. C.","family":"Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto A.","family":"Gabbai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Str\u00f6bel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Glatzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriano","family":"Aguzzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert","family":"Budka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,12,30]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90436-7"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.278.5336.245"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.052707499"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.embor.embor827"},{"key":"e_1_2_6_6_2","first-page":"135","article-title":"Histopathology and immunohistochemistry of human transmissible spongiform encephalopathies (TSEs)","volume":"16","author":"Budka H","year":"2000","journal-title":"Arch Virol"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64705-0"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/60.1.1"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2001.tb00390.x"},{"key":"e_1_2_6_10_2","unstructured":"World Health Organization.Global surveillance diagnosis and therapy of human transmissible spongiform encephalopathies: report of a WHO consultation. Presented at: WHO\/EMC\/ZDI;1998; Geneva Switzerland."},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2002.tb00417.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(199908)46:2<224::AID-ANA12>3.0.CO;2-W"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/2654"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdf653"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg125"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)24002-X"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64474-4"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.8.1235"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.2.368"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.10813","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.10813","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T02:26:28Z","timestamp":1695954388000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.10813"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,12,30]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,1]]}},"alternative-id":["10.1002\/ana.10813"],"URL":"https:\/\/doi.org\/10.1002\/ana.10813","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,12,30]]}}}