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We examined the functional status of the D<jats:sub>1<\/jats:sub> receptor in brain of patients with Parkinson's disease (PD), multiple system atrophy (MSA), and progressive supranuclear palsy (PSP). Dopamine\u2010stimulated adenylyl cyclase activity was significantly increased in putamen (+43%) and frontal cortex (+52%) in PD, normal in PSP, but decreased by 47% in putamen in MSA. The supersensitive dopamine D<jats:sub>1<\/jats:sub> receptors in both striatum and cerebral cortex in PD might compensate for dopamine deficiency, but could also contribute to long\u2010term complications of levodopa therapy.<\/jats:p>","DOI":"10.1002\/ana.10814","type":"journal-article","created":{"date-parts":[[2003,12,31]],"date-time":"2003-12-31T09:34:51Z","timestamp":1072863291000},"page":"125-129","source":"Crossref","is-referenced-by-count":29,"title":["Brain dopamine\u2010stimulated adenylyl cyclase activity in Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy"],"prefix":"10.1002","volume":"55","author":[{"given":"Junchao","family":"Tong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul S.","family":"Fitzmaurice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee Cyn","family":"Ang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiaki","family":"Furukawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Guttman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Kish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,12,30]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.58.2.249"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(99)00045-4"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/111.2.299"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.71.10.3883"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/295696a0"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(97)01067-4"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.74.5.2126"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1353-8020(01)00020-7"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-0186(01)00016-X"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(98)00304-9"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.11.2015"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65226-1"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(83)90993-9"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410180503"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1992.tb10939.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2944(78)90036-4"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01250323"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4832-8363-0.50499-7"},{"key":"e_1_2_6_20_2","first-page":"215","article-title":"Neurochemical and neuroreceptor imaging with PET in Parkinson's disease","volume":"86","author":"Stoessl AJ","year":"2001","journal-title":"Adv Neurol"},{"key":"e_1_2_6_21_2","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1007\/s004010100372","article-title":"Choline acetytransferase activity and striatal dopamine receptors in Parkinson's disease in relation to cognitive impairment","volume":"102","author":"Mattila PM","year":"2001","journal-title":"Acta Neuropathol (Berl)"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.10814","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.10814","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T02:26:30Z","timestamp":1695954390000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.10814"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,12,30]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,1]]}},"alternative-id":["10.1002\/ana.10814"],"URL":"https:\/\/doi.org\/10.1002\/ana.10814","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,12,30]]}}}