{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T13:23:21Z","timestamp":1789910601286,"version":"4.0.1"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2001,7,3]],"date-time":"2001-07-03T00:00:00Z","timestamp":994118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2001,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Two anti\u2010neuronal nuclear antibodies (ANNA\u20101 and ANNA\u20102) are markers of paraneoplastic neurological autoimmunity related to small\u2010cell carcinoma. ANNA\u20102 is also related to breast carcinoma. Here we define a third IgG specificity (ANNA\u20103), identified in 11 patients (10 adults) by immunofluorescence screening of sera from approximately 68,000 patients with suspected paraneoplastic neurological syndromes. ANNA\u20103 binds prominently to nuclei of cerebellar Purkinje neurons, not to cytoplasm, granular neurons, or enteric neurons, but distinctively to renal glomerular podocytes. Western blots revealed an approximately 170 kDa antigen, in cerebellum and small\u2010cell carcinoma. IgG eluted from this protein reproduced Purkinje and podocyte nuclear staining. ANNA\u20102 in 8 of 32 cases bound to podocyte nuclei but not to the 170 kDa protein. Healthy subjects and control neurological and cancer patients lack ANNA\u20103. Neurological accompaniments, subacute and usually multifocal, included sensory\/sensorimotor neuropathies, cerebellar ataxia, myelopathy, brain stem and limbic encephalopathy. All of 9 adults followed had an intrathoracic neoplasm, seven biopsied within 7 months (five small\u2010cell lung carcinomas and two adenocarcinomas, one lung, one esophagus) and two imaged, one early, the other 3 years later. Thus, immunohistochemical and Western blot criteria can now identify six IgG markers of neurological autoimmunity related to small\u2010cell carcinoma, their frequency being ANNA\u20101 &gt; collapsin response\u2010mediator protein\u20105 &gt; amphiphysin &gt; Purkinje cell cytoplasmic antibody\u20102 = ANNA\u20102 = ANNA\u20103.<\/jats:p>","DOI":"10.1002\/ana.1127","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T19:58:07Z","timestamp":1030305487000},"page":"301-311","source":"Crossref","is-referenced-by-count":142,"title":["ANNA\u20103 anti\u2010neuronal nuclear antibody: Marker of lung cancer\u2010related autoimmunity"],"prefix":"10.1002","volume":"50","author":[{"given":"Koon Ho","family":"Chan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Vernino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanda 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