{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T01:53:36Z","timestamp":1780106016618,"version":"3.54.0"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,4,12]],"date-time":"2004-04-12T00:00:00Z","timestamp":1081728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2004,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There are no known anatomical connections between neurons that innervate homologous right and left body parts. Nevertheless, some patients develop bilateral abnormalities after unilateral injury, a phenomenon often unrecognized and not yet characterized. Therefore, we examined in rats the effects of ligating and cutting one tibial nerve on sensory function and on density of innervation in hind paws contralaterally as well as ipsilaterally to the injury, at times between 1 day and 5 months after surgery. Punches removed from tibial\u2010 or sural\u2010innervated planter paw skin were immunolabeled to quantitate epidermal nerve endings. Naive and sham\u2010operated rats provided controls. Axotomized rats had near\u2010total loss of PGP9.5<jats:sup>+<\/jats:sup> innervation within ipsilateral tibial\u2010innervated skin at all time\u2010points. Adjacent ipsilateral sural\u2010innervated skin had persistent hyperalgesia without denervation, and robust axonal sprouting at 5 months after surgery. Contralesional hind paws lost 54% of innervation in tibial\u2010innervated epidermis starting 1 week after surgery and persisting throughout. Contralesional sural\u2010innervated skin had neither neurite loss nor sprouting. These results imply that unilateral nerve injury can cause profound, long lasting, nerve\u2013branch\u2013specific loss of distal innervation contralaterally as well as ipsilaterally. They discredit the practice of using tissues contralateral to an injury to provide normative controls and suggest the possibility of rapid, transmedian postinjury signals between homologous mirror\u2010image neurons.<\/jats:p>","DOI":"10.1002\/ana.20048","type":"journal-article","created":{"date-parts":[[2004,4,13]],"date-time":"2004-04-13T09:05:46Z","timestamp":1081847146000},"page":"639-644","source":"Crossref","is-referenced-by-count":87,"title":["Unilateral nerve injury produces bilateral loss of distal innervation"],"prefix":"10.1002","volume":"55","author":[{"given":"Anne Louise","family":"Oaklander","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer M.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,4,12]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"1872","volume-title":"Injuries of nerves and their consequences","author":"Mitchell SW"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(76)90748-8"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410440513"},{"key":"e_1_2_6_5_2","unstructured":"WatsonCPN MidhaR DevorM et al.Trigeminal postherpetic neuralgia postmortem: clinically unilateral pathologically bilateral. In: Devor M Rowbotham MC Weisenfeld\u2010Hallin Z eds. Proceedings of the 9th World Congress on Pain. Seattle: IASP Press 2000:733\u2013739."},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(97)00239-8"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(98)01302-2"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(01)00354-2"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/363543a0"},{"key":"e_1_2_6_10_2","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1523\/JNEUROSCI.17-05-01776.1997","article-title":"Phosphorylation of transcription factor CREB in rat spinal cord after formalin\u2010induced hyperalgesia: relationship to c\u2010fos induction","volume":"17","author":"Ji RR","year":"1997","journal-title":"J Neurosci"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(90)90631-I"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1985.sp015623"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(90)91074-S"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(94)90083-3"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(98)00245-0"},{"key":"e_1_2_6_16_2","doi-asserted-by":"crossref","first-page":"6926","DOI":"10.1523\/JNEUROSCI.15-10-06926.1995","article-title":"Recovery of tail\u2010elicited siphon\u2010withdrawal reflex following unilateral axonal injury is associated with ipsi\u2010 and contralateral changes in gene expression in Aplysia californica","volume":"15","author":"Noel F","year":"1995","journal-title":"J Neurosci"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19970407)380:2<164::AID-CNE2>3.0.CO;2-1"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901850113"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(83)90201-4"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(00)00276-1"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(94)90013-2"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(94)90023-X"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(83)90241-X"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.10.1848"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12613631"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026519720352"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(88)90209-6"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(02)00039-8"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1529-8027.2001.006001111.x"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-002-0527-7"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(91)90393-8"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(02)00350-0"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.20048","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.20048","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T13:00:22Z","timestamp":1697461222000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.20048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,4,12]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2004,5]]}},"alternative-id":["10.1002\/ana.20048"],"URL":"https:\/\/doi.org\/10.1002\/ana.20048","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,4,12]]}}}