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A blinded comparison was performed between the extent of parenchymal hemorrhage and initial clinical variables as well as outcomes measured at 6 to 12 months after injury. Children with lower Glasgow Coma Scale scores (\u22648, n = 30) or prolonged coma (&gt;4 days, n = 20) had a greater average number (<jats:italic>p<\/jats:italic> = 0.007) and volume (<jats:italic>p<\/jats:italic> = 0.008) of hemorrhagic lesions. Children with normal outcomes or mild disability (n = 30) at 6 to 12 months had, on average, fewer hemorrhagic lesions (<jats:italic>p<\/jats:italic> = 0.003) and lower volume (<jats:italic>p<\/jats:italic> = 0.003) of lesions than those who were moderately or severely disabled or in a vegetative state. Significant differences also were observed when comparing regional injury to clinical variables. Because susceptibility\u2010weighted imaging is much more sensitive than conventional T2*\u2010weighted gradient\u2010echo sequences in detecting hemorrhagic diffuse axonal injury, more accurate and objective assessment of injury can be obtained early after insult, and may provide better prognostic information regarding duration of coma as well as long\u2010term outcome. Ann Neurol 2004;56:36\u201350<\/jats:p>","DOI":"10.1002\/ana.20123","type":"journal-article","created":{"date-parts":[[2004,6,28]],"date-time":"2004-06-28T17:06:09Z","timestamp":1088442369000},"page":"36-50","source":"Crossref","is-referenced-by-count":288,"title":["Diffuse axonal injury in children: Clinical correlation with hemorrhagic lesions"],"prefix":"10.1002","volume":"56","author":[{"given":"Karen A.","family":"Tong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Ashwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara A.","family":"Holshouser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua P.","family":"Nickerson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Wall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori A.","family":"Shutter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renatta J.","family":"Osterdock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. 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