{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:48:38Z","timestamp":1762390118991},"reference-count":70,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,7,19]],"date-time":"2004-07-19T00:00:00Z","timestamp":1090195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2004,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Immune responses against gangliosides are strongly implicated in the pathogenesis of some variants of Guillain\u2013Barr\u00e9 syndrome (GBS). For example, IgG antibodies against GM1, GD1a, and related gangliosides are frequently present in patients with post\u2010<jats:italic>Campylobacter<\/jats:italic> acute motor axonal neuropathy (AMAN) variant of GBS, and immunization of rabbits with GM1 has produced a model of AMAN. However, the role of anti\u2010ganglioside antibodies in GBS continues to be debated because of lack of a passive transfer model. We recently have raised several monoclonal IgG anti\u2010ganglioside antibodies. We passively transfer these antibodies by intraperitoneal hybridoma implantation and by systemic administration of purified anti\u2010ganglioside antibodies in mice. Approximately half the animals implanted with an intraperitoneal clone of anti\u2010ganglioside antibody\u2010secreting hybridoma developed a patchy, predominantly axonal neuropathy affecting a small proportion of nerve fibers. In contrast to hybridoma implantation, passive transfer with systemically administered anti\u2010ganglioside antibodies did not cause nerve fiber degeneration despite high titre circulating antibodies. Blood\u2013nerve barrier studies indicate that animals implanted with hybridoma had leaky blood\u2013nerve barrier compared to mice that received systemically administered anti\u2010ganglioside antibodies. Our findings suggest that in addition to circulating antibodies, factors such as antibody accessibility and nerve fiber resistance to antibody\u2010mediated injury play a role in the development of neuropathy. 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