{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:30:24Z","timestamp":1777933824520,"version":"3.51.4"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,8,9]],"date-time":"2004-08-09T00:00:00Z","timestamp":1092009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2004,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>It has been hypothesized that hypothalamus is involved in narcolepsy. The relative difference between cerebral glucose metabolism of 24 narcoleptic patients and 24 normal controls was studied using <jats:sup>18<\/jats:sup>F\u2010fluorodeoxy glucose positron emission tomography. Patients with narcolepsy showed significantly reduced cerebral glucose metabolism in bilateral rectal and subcallosal gyri, the medial convexity of right superior frontal gyrus, bilateral precuneus, right inferior parietal lobule, and in left supramarginal gyrus (uncorrected <jats:italic>p<\/jats:italic> &lt; 0.001). Bilateral posterior hypothalami and mediodorsal thalamic nuclei showed hypometabolism with significance at the level of corrected <jats:italic>p<\/jats:italic> &lt; 0.05, with small volume correction. This study showed cerebral glucose hypometabolism of the hypothalamus\u2010thalamus\u2010orbitofrontal pathways in the narcoleptic brain. Ann Neurol 2004<\/jats:p>","DOI":"10.1002\/ana.20212","type":"journal-article","created":{"date-parts":[[2004,8,10]],"date-time":"2004-08-10T07:24:44Z","timestamp":1092122684000},"page":"437-440","source":"Crossref","is-referenced-by-count":67,"title":["Glucose hypometabolism of hypothalamus and thalamus in narcolepsy"],"prefix":"10.1002","volume":"56","author":[{"given":"Eun Yeon","family":"Joo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woo Suk","family":"Tae","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jee Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byung Tae","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Bong","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,8,31]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"676","volume-title":"Principles and practice of sleep medicine","author":"Guilleminault C","year":"2000"},{"key":"e_1_2_6_3_2","first-page":"702","article-title":"Kleine\u2010Levin syndrome: two cases","volume":"17","author":"SK Lee","year":"1999","journal-title":"J Korean Neurol Assoc"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1102-1186"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.12.1852"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.2.410"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(96)00003-0"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.5.1297"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.1037"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10444"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)00058-1"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.25.112701.142826"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80949-6"},{"key":"e_1_2_6_14_2","first-page":"44","article-title":"Voxel\u2010based morphometry in hypocretin\u2010deficient narcolepsy","volume":"26","author":"Overeem S","year":"2003","journal-title":"Sleep"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-23-09996.1998"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004691-200103000-00002"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/386824a0"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1389-9457(03)00059-5"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1080\/01688638508401239"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1162\/08989290051137585"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.20212","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.20212","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T02:57:06Z","timestamp":1700276226000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.20212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,8,31]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2004,9]]}},"alternative-id":["10.1002\/ana.20212"],"URL":"https:\/\/doi.org\/10.1002\/ana.20212","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,8,31]]}}}