{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T19:33:29Z","timestamp":1760729609741},"reference-count":52,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,9,9]],"date-time":"2004-09-09T00:00:00Z","timestamp":1094688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2004,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>PAX6<\/jats:italic> mutations are associated with absence\/hypoplasia of the anterior commissure and reduction in the callosal area in humans. Both of these structures contain auditory interhemispheric fibers. The aim of this study was to characterize central auditory function in patients with a <jats:italic>PAX6<\/jats:italic> mutation. We conducted central auditory tests (dichotic speech, pattern, and gaps in noise tests) on eight subjects with a <jats:italic>PAX6<\/jats:italic> mutation and eight age\u2010 and sex\u2010matched controls. Brain magnetic resonance imaging showed absent\/hypoplastic anterior commissure in six and a hypoplastic corpus callosum in three <jats:italic>PAX6<\/jats:italic> subjects. The control group gave normal central auditory tests results. All the <jats:italic>PAX6<\/jats:italic> subjects gave abnormal results in at least two tests that require interhemispheric transfer, and all but one gave normal results in a test not requiring interhemispheric transfer. The left ear scores in the dichotic speech tests was significantly lower in the <jats:italic>PAX6<\/jats:italic> than in the control group. These results are consistent with deficient auditory interhemispheric transfer in patients with a <jats:italic>PAX6<\/jats:italic> mutation, which may be attributable to structural and\/or functional abnormalities of the anterior commisure and corpus callosum, although the exact contribution of these two formations to our findings remains unclear. Our unique findings broaden the possible functions of <jats:italic>PAX6<\/jats:italic> to include neurodevelopmental roles in higher order auditory processing. Ann Neurol 2004<\/jats:p>","DOI":"10.1002\/ana.20227","type":"journal-article","created":{"date-parts":[[2004,9,14]],"date-time":"2004-09-14T08:51:13Z","timestamp":1095151873000},"page":"503-509","source":"Crossref","is-referenced-by-count":33,"title":["Deficient auditory interhemispheric transfer in patients with <i>PAX6<\/i> mutations"],"prefix":"10.1002","volume":"56","author":[{"given":"Doris\u2010Eva","family":"Bamiou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank E.","family":"Musiek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjay M.","family":"Sisodiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha L.","family":"Free","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosalyn A.","family":"Davies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Moore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronica","family":"van Heyningen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda M.","family":"Luxon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,9,9]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/11.10.1161"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/90042"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0012-1606(02)00046-5"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.129.21.5041"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10219"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002210050593"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000106950.74155.0A"},{"key":"e_1_2_5_9_2","first-page":"47","volume-title":"Two hemispheres\u2010one brain. 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