{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T17:13:59Z","timestamp":1793726039758,"version":"4.6.1"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,10,27]],"date-time":"2004-10-27T00:00:00Z","timestamp":1098835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Association Fran\u00e7aise contre les Myopathies"},{"name":"Facult\u00e9 de M\u00e9decine Piti\u00e9-Salp\u00eatri\u00e8re"},{"name":"Assistance Publique-H\u00f4pitaux de Paris"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2004,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Polymyositis is a CD8<jats:sup>+<\/jats:sup> T\u2010cell\u2013mediated disease. T\u2010cell clonal expansions are observed at disease onset, but little is known about their persistence over time. Qualitative and quantitative spectratyping demonstrated that PM relapse features dramatically perturbed blood T\u2010cell repertoires but is not associated with the emergence of new T\u2010cell clones. It is striking that patients in remission also maintained all their T\u2010cell repertoire abnormalities. The clonally expanded T\u2010cells displayed a memory phenotype, expressed intracellular perforin, and dramatically responded to IL\u20102, showing a potential to be reactivated upon appropriate conditions. These results indicate that persistent T\u2010cell clonal expansion is an important feature of polymyositis. Ann Neurol 2004<\/jats:p>","DOI":"10.1002\/ana.20293","type":"journal-article","created":{"date-parts":[[2004,11,8]],"date-time":"2004-11-08T18:38:46Z","timestamp":1099939126000},"page":"867-872","source":"Crossref","is-referenced-by-count":37,"title":["Long\u2010term persistence of clonally expanded T cells in patients with polymyositis"],"prefix":"10.1002","volume":"56","author":[{"given":"Olivier","family":"Benveniste","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge","family":"Herson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beno\u00eet","family":"Salomon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalia","family":"Dimitri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Tr\u00e9beden\u2010N\u00e8gre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laetitia","family":"Jean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Bon\u2010Durand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Antonelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Klatzmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Boyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,27]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(86)80180-0"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410290509"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199111213252107"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116533"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830241114"},{"key":"e_1_2_6_7_2","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.4049\/jimmunol.152.5.2569","article-title":"Predominant TCR\u2010\u03b1 \u03b2 variable and joining gene expression by muscle\u2010infiltrating lymphocytes in the idiopathic inflammatory myopathies","volume":"152","author":"O'Hanlon TP","year":"1994","journal-title":"J Immunol"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.181.5.1863"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.6.3521"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.7.4051"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0236183100"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199812)21:12<1668::AID-MUS7>3.0.CO;2-#"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.9.4319"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0298-215"},{"key":"e_1_2_6_15_2","doi-asserted-by":"crossref","first-page":"16","DOI":"10.4049\/jimmunol.144.1.16","article-title":"Inhibition of antigen\u2010specific proliferation of type 1 murine T cell clones after stimulation with immobilized anti\u2010CD3 monoclonal antibody","volume":"144","author":"Jenkins MK","year":"1990","journal-title":"J Immunol"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01152"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20011629"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.20293","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.20293","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T15:37:46Z","timestamp":1696952266000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.20293"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,10,27]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2004,12]]}},"alternative-id":["10.1002\/ana.20293"],"URL":"https:\/\/doi.org\/10.1002\/ana.20293","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,10,27]]}}}