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The ADP levels are calculated using the creatine kinase equilibrium and quantified <jats:sup>31<\/jats:sup>P and total creatine measurements. Using high\u2010field quantitative MR spectroscopic imaging, we find that NAA and ADP concentrations in the hippocampal body are 9.7 \u00b1 1.5mM and 35 \u00b1 8\u03bcM, respectively. In the occipital lobe, NAA and ADP are 11.9 \u00b1 1.9mM and 32 \u00b1 12\u03bcM, respectively. There is a statistically significant positive correlation between NAA and ADP, with <jats:italic>R<\/jats:italic> = +0.80, <jats:italic>p<\/jats:italic> &lt; 2 \u00d7 10<jats:sup>\u22127<\/jats:sup>in the hippocampal body. In an adjacent hippocampal NAA voxel, the correlation between NAA and ADP had a <jats:italic>R<\/jats:italic> = +0.62, <jats:italic>p<\/jats:italic> &lt; 3 \u00d7 10<jats:sup>\u22124<\/jats:sup>, whereas, in the occipital lobe, <jats:italic>R<\/jats:italic> = +0.67, <jats:italic>p<\/jats:italic> &lt; 5 \u00d7 10<jats:sup>\u22125<\/jats:sup>. There was no significant relationship NAA and either ATP or phosphocreatine. This positive relationship of NAA with ADP suggests a directional process wherein energetics may modulate mitochondrial function. Ann Neurol 2004.<\/jats:p>","DOI":"10.1002\/ana.20317","type":"journal-article","created":{"date-parts":[[2004,11,16]],"date-time":"2004-11-16T01:16:26Z","timestamp":1100567786000},"page":"92-97","source":"Crossref","is-referenced-by-count":67,"title":["Interdependence of <i>N<\/i>\u2010acetyl aspartate and high\u2010energy phosphates in healthy human brain"],"prefix":"10.1002","volume":"57","author":[{"given":"Jullie W.","family":"Pan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kan","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,11,15]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"crossref","first-page":"4257","DOI":"10.1016\/S0021-9258(17)36410-4","article-title":"The enzymatic synthesis of N\u2010acetyl\u2010L\u2010aspartic acid by subcellular preparations of rat brain","volume":"244","author":"Goldstein FB","year":"1969","journal-title":"J Biol Chem"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1992.tb08875.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199605310-00014"},{"key":"e_1_2_6_5_2","first-page":"1359","article-title":"Multisection proton MR spectroscopy for mesial temporal lobe epilepsy","volume":"23","author":"Capizzano A","year":"2002","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410380309"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410350213"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002340000521"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/135245850000600303"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910360113"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.2.210"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj1840539"},{"key":"e_1_2_6_13_2","first-page":"149","article-title":"Selective vulnerability in brain hypoxia","volume":"6","author":"Cervos\u2010Navarro J","year":"1991","journal-title":"Crit Rev Neurobiol"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/1522-2594(200101)45:1<46::AID-MRM1008>3.0.CO;2-N"},{"key":"e_1_2_6_15_2","unstructured":"ChuWJ PanC PanJW HetheringtonHP.Reproducibility of 1H MR spectroscopic imaging of the human hippocampus. 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