{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:51:51Z","timestamp":1790484711296,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,2,28]],"date-time":"2005-02-28T00:00:00Z","timestamp":1109548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2005,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Two studies found that stroke patients with intracranial arterial dolichoectasia (IADE) had lacunar infarction more often than the control subjects. The relation between IADE and other manifestations of small\u2010vessel disease (multilacunar state, leukoaraiosis, and \u00e9tat cribl\u00e9) was not investigated. The magnetic resonance images of 510 patients with brain infarction in the Etude du Profil Genetique de l'Infarctus Cerebral (GENIC) study were evaluated for the diagnosis of multilacunar infarction (&gt;1 lacunar infarct), leukoaraiosis (assessed in periventricular and subcortical regions according to Scheltens and colleagues' scale, with severe leukoaraiosis defined as a score &gt; 8), \u00e9tat cribl\u00e9 (using a semiquantitative score ranging from 0\u20138, with severe EC &gt; 4), and IADE (using the consensus method). By comparison with stroke patients without IADE (n = 447), IADE(+) stroke patients (n = 63) had significantly more frequent multilacunar state (51 vs 33%), severe leukoaraiosis (34 vs 19%), and severe \u00e9tat cribl\u00e9 (32 vs 12%). After adjustment for potential confounding factors, the odds ratios (95% confidence interval) for the presence of IADE were 2.05 (1.08\u20133.87) for multilacunar state, 2.40 (1.11\u20135.20) for severe leukoaraiosis, and 3.60 (1.43\u20139.08) for severe \u00e9tat cribl\u00e9. The factors significantly associated with \u00e9tat cribl\u00e9 were older age and a familial history of stroke. IADE in stroke patients was independently associated with parenchymal manifestations of small\u2010vessel disease. These conditions may have in common underlying pathophysiological processes. Ann Neurol 2005<\/jats:p>","DOI":"10.1002\/ana.20423","type":"journal-article","created":{"date-parts":[[2005,2,28]],"date-time":"2005-02-28T22:17:24Z","timestamp":1109629044000},"page":"472-479","source":"Crossref","is-referenced-by-count":102,"title":["Intracranial arterial dolichoectasia and small\u2010vessel disease in stroke patients"],"prefix":"10.1002","volume":"57","author":[{"given":"Fernando","family":"Pico","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Labreuche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre\u2010Jean","family":"Touboul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Leys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Amarenco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the GENIC Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,3,18]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000103168.14885.A8"},{"key":"e_1_2_6_3_2","first-page":"55","article-title":"High\u2010resolution computed tomography of the basilar artery: 1. 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