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Network analysis demonstrated that dopa\u2010responsive dystonia is associated with a specific pattern of regional metabolic covariation, characterized by increases in the dorsal midbrain, cerebellum, and supplementary motor area, as well as reductions in motor and lateral premotor cortex and in the basal ganglia. This pattern was not expressed in mutation carriers for primary torsion dystonia. Dopa\u2010responsive dystonia has a unique metabolic architecture that differs from other inherited forms of dystonia. 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