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Herein, we measured 12(S)\u2010HETE and 15(S)\u2010HETE levels, products of 12\/15LOX, in cerebrospinal fluid (CSF) of normal individuals, subjects with mild cognitive impairment (MCI) and AD. Compared with controls, there was a significant increase of both metabolites in CSF from AD and MCI, which correlated with lipid peroxidation and tau protein levels. These results suggest that the activation of this enzyme occurs early in the course of AD, before the onset of overt dementia, thereby implicating 12\/15LOX\u2010mediated lipid peroxidation in the pathogenesis of AD. Ann Neurol 2005<\/jats:p>","DOI":"10.1002\/ana.20558","type":"journal-article","created":{"date-parts":[[2005,7,21]],"date-time":"2005-07-21T20:47:29Z","timestamp":1121978849000},"page":"623-626","source":"Crossref","is-referenced-by-count":112,"title":["Elevation of 12\/15 lipoxygenase products in AD and mild cognitive impairment"],"prefix":"10.1002","volume":"58","author":[{"given":"Yuemang","family":"Yao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M.","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Q.","family":"Trojanowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia M.\u2010Y.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Pratic\u00f2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,7,21]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2004-6209"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(00)00141-X"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.34.23679"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(99)00396-8"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/41.1.8417106"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63724-8"},{"issue":"1","key":"e_1_2_6_8_2","first-page":"15","article-title":"Fisher symposium: strategies for the prevention of Alzheimer's disease\u2014an overview of research planning meeting III","volume":"10","author":"Radebaugh TS","year":"1996","journal-title":"Alzheim Dis Assoc Disord"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.4.609"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002093-199601010-00006"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.59.6.972"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(200011)48:5<809::AID-ANA19>3.0.CO;2-9"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410380414"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-2760(01)00411-8"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/328038a0"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80953-8"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/22572"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.20558","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.20558","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T22:58:28Z","timestamp":1695941908000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.20558"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,7,21]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,10]]}},"alternative-id":["10.1002\/ana.20558"],"URL":"https:\/\/doi.org\/10.1002\/ana.20558","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,7,21]]}}}