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Eighty\u2010nine patients with neocortical epilepsy with normal magnetic resonance imaging (35 patients with frontal lobe epilepsy, 31 with neocortical temporal lobe epilepsy, 11 with occipital lobe epilepsy, 11 with parietal lobe epilepsy, and 1 with multifocal epilepsy) underwent invasive study and focal surgical resection. Patients were observed for at least 2 years after surgery. The localizing values of interictal electroencephalogram (EEG), ictal scalp EEG, interictal <jats:sup>18<\/jats:sup>F\u2010fluorodeoxyglucose positron emission tomography (FDG\u2010PET), and subtraction ictal single\u2010photon emission computed tomography were evaluated. Seventy\u2010one patients (80.0%) had a good surgical outcome (Engel class 1\u20133); 42 patients were seizure free. Diagnostic sensitivities of interictal EEG, ictal scalp EEG, FDG\u2010PET, and subtraction ictal single\u2010photon emission computed tomography were 37.1%, 70.8%, 44.3%, and 41.1%, respectively. Localization by FDG\u2010PET and interictal EEG was correlated with a seizure\u2010free outcome. The localizing value of FDG\u2010PET was greatest in neocortical temporal lobe epilepsy. The focalization of ictal onset and also ictal onset frequency in invasive studies were not related to surgical outcome. Concordance with two or more presurgical evaluations was significantly related to a seizure\u2010free outcome. 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