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Mutations in each of the five subunits of eIF2B have been identified. We report in an affected man and his mother an adult\u2010onset form of childhood ataxia with central nervous system hypomyelination\/vanishing white matter disease\u2013like disorder with no mutations in the <jats:italic>EIF2B<\/jats:italic> genes and normal guanine nucleotide exchange factor eIF2B activity, suggesting a new dominant inheritance of this syndrome that may involve other genes. 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