{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T06:07:33Z","timestamp":1790489253180,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,9,21]],"date-time":"2005-09-21T00:00:00Z","timestamp":1127260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2005,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In contrast with other systemic rheumatic diseases in childhood, no systematic studies exist that focus on possible long\u2010term risks for central nervous system involvement in systemic juvenile rheumatoid arthritis (SJRA). We investigated 31 children and adolescents with SJRA, aged 6 to 24 years (mean, 12.5 years; standard deviation, 4.3 years), with mean disease duration of 6.2 years (standard deviation, 3.5 years; range, 0.6\u201314 years) for their cognitive and fine motor abilities. We also examined 31 matched healthy control subjects. In addition, parents assessed social activities and social and emotional problems in their children. Patients and control subjects performed within normal limits of intelligence quotient, memory and learning, attention, and fine motor scores. Less social activities were reported for patients. Patients and control subjects, however, had normal social and emotional problem scores. SJRA, although a burdensome chronic disease, is not associated with cognitive impairment or increased social and emotional problems. Cognitive performance and social adjustment of young patients with SJRA are not affected by disease activity and duration. Ann Neurol 2005;58:605\u2013609<\/jats:p>","DOI":"10.1002\/ana.20626","type":"journal-article","created":{"date-parts":[[2005,9,21]],"date-time":"2005-09-21T23:21:28Z","timestamp":1127344888000},"page":"605-609","source":"Crossref","is-referenced-by-count":32,"title":["Systemic juvenile rheumatoid arthritis: Cognitive function and social adjustment"],"prefix":"10.1002","volume":"58","author":[{"given":"Reinhold","family":"Feldmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"Weglage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Roth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Foell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Frosch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,9,21]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.11177"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)60640-X"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.11205"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780241109"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0303-8467(88)90034-0"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-8994(98)00022-8"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.3109\/rhe1.1968.14.issue-1-4.24"},{"key":"e_1_2_5_9_2","volume-title":"Textbook of pediatric rheumatology","author":"Cassidy JT","year":"1995"},{"key":"e_1_2_5_10_2","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1542\/peds.53.4.523","article-title":"Psychological problems of children with chronic juvenile arthritis","volume":"53","author":"McAnarney ER","year":"1974","journal-title":"Pediatrics"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10444"},{"key":"e_1_2_5_12_2","first-page":"1989","article-title":"Disease course and outcome of juvenile rheumatoid arthritis in a multicenter cohort","volume":"29","author":"Oen K","year":"2002","journal-title":"J Rheumatol"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/28.1.29"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.103.5.975"},{"issue":"38","key":"e_1_2_5_15_2","first-page":"1","article-title":"Psychosocial factors related to rheumatic diseases in childhood","volume":"20","author":"Miller JJ","year":"1993","journal-title":"J Rheumatol"},{"key":"e_1_2_5_16_2","first-page":"561","article-title":"Psychosocial outcome in juvenile chronic arthritis: a nine\u2010year follow up","volume":"15","author":"Aasland A","year":"1997","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_5_17_2","first-page":"1991","article-title":"Revision of the proposed classification criteria for juvenile idiopathic arthritis: Durban, 1997","volume":"25","author":"Petty RE","year":"1998","journal-title":"J Rheumatol"},{"key":"e_1_2_5_18_2","first-page":"390","article-title":"International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001","volume":"31","author":"Petty RE","year":"2004","journal-title":"J Rheumatol"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400703"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780241012"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.57.1.38"},{"key":"e_1_2_5_22_2","volume-title":"Wechsler Adult Intelligence Scale\u2013Revised","author":"Wechsler D","year":"1981"},{"key":"e_1_2_5_23_2","volume-title":"Wechsler Intelligence Scales for Children\u2013Revised","author":"Wechsler D","year":"1974"},{"key":"e_1_2_5_24_2","volume-title":"Der Zahlen\u2010Verbindungs\u2010Test (ZVT)","author":"Oswald WD","year":"1987"},{"key":"e_1_2_5_25_2","volume-title":"Diagnosticum f\u00fcr Cerebralsch\u00e4digung nach F. Hillers","author":"Weidlich S","year":"1993"},{"key":"e_1_2_5_26_2","first-page":"21","article-title":"VLMT: Verbaler Lern\u2010 und Merkf\u00e4higkeitstest","volume":"141","author":"Helmstaedter C","year":"1990","journal-title":"Schweiz Arch Neurol Psychiatr"},{"key":"e_1_2_5_27_2","first-page":"129","article-title":"Die Leistungen von 7\u2010 bis 15j\u00e4hrigen Kindern im Verbalen Lern\u2010 und Merkf\u00e4higkeits\u2010Test (VLMT)","volume":"8","author":"Schweisthal B","year":"1997","journal-title":"Z Neuropsychol"},{"key":"e_1_2_5_28_2","volume-title":"Test d2. Aufmerksamkeits\u2010Belastungs\u2010Test","author":"Brickenkamp R","year":"1994"},{"key":"e_1_2_5_29_2","first-page":"43","article-title":"Das MLS\u2010Ger\u00e4t: Ein neuer Testapparat zur Messung feinmotorischer Leistungen","volume":"20","author":"Schoppe KJ","year":"1974","journal-title":"Diagnostica"},{"key":"e_1_2_5_30_2","volume-title":"Motorische Leistungsserie","author":"Schuhfried G","year":"1981"},{"key":"e_1_2_5_31_2","volume-title":"Manual for the Child Behaviour Checklist\/4\u201018 and 1991 profile","author":"Achenbach TM","year":"1991"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1177\/088307389400900315"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/40.11.1293"},{"key":"e_1_2_5_34_2","first-page":"2059","article-title":"Severe central nervous system involvement in juvenile dermatomyositis","volume":"30","author":"Elst EF","year":"2003","journal-title":"J Rheumatol"},{"key":"e_1_2_5_35_2","first-page":"417","article-title":"Neuropsychologic deficits and antineuronal antibodies in pediatric systemic lupus erythematosus","volume":"8","author":"Papero PH","year":"1990","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_5_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02041564"},{"key":"e_1_2_5_37_2","first-page":"623","article-title":"Cerebral complications in juvenile rheumatoid arthritis","volume":"107","author":"Jan JE","year":"1972","journal-title":"Can Med Assoc J"},{"key":"e_1_2_5_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1974.tb04813.x"},{"key":"e_1_2_5_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1978.tb16367.x"},{"key":"e_1_2_5_40_2","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/jsh004"},{"key":"e_1_2_5_41_2","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/27.2.155"},{"key":"e_1_2_5_42_2","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/17.3.277"},{"key":"e_1_2_5_43_2","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/28.1.17"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.20626","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.20626","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T22:57:28Z","timestamp":1695941848000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.20626"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9,21]]},"references-count":42,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,10]]}},"alternative-id":["10.1002\/ana.20626"],"URL":"https:\/\/doi.org\/10.1002\/ana.20626","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,9,21]]}}}