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Two members of our kindred were affected with motor neuron disease and two with dementia in an autosomal dominant pattern of inheritance. We excluded the involvement of the ALS and FTD\u2010linked genes for copper\/zinc superoxide dismutase (SOD1) and tau. The R1101K sequence alteration of the <jats:italic>DCTN1<\/jats:italic> gene may predispose subjects to ALS and FTD. 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