{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T18:41:37Z","timestamp":1698777697466},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,10,20]],"date-time":"2005-10-20T00:00:00Z","timestamp":1129766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2005,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Current knowledge of Epstein\u2013Barr virus (EBV)\u2013specific T\u2010cell responses in the cerebrospinal fluid (CSF) of patients with EBV\u2010related lymphoproliferative disease (EBV\u2010LPD) in the central nervous system (CNS) is very limited. Here, we present two recipients of hematopoietic stem cell transplants with EBV\u2010LPD in the CNS. EBV\u2010specific CD8<jats:sup>+<\/jats:sup> T lymphocytes were detected in CSF and peripheral blood using major histocompatibility complex (MHC) class I multimers loaded with EBV\u2010derived peptides. The appearance of EBV\u2010specific CD8<jats:sup>+<\/jats:sup> T cells in CSF and blood correlated with neurological improvement and disappearance of EBV\u2010LPD. These observations suggest a role for EBV\u2010specific CD8<jats:sup>+<\/jats:sup> T cells in the control of EBV\u2010LPD in the CNS. Ann Neurol 2005;58:788\u2013792<\/jats:p>","DOI":"10.1002\/ana.20640","type":"journal-article","created":{"date-parts":[[2005,10,20]],"date-time":"2005-10-20T18:19:01Z","timestamp":1129832341000},"page":"788-792","source":"Crossref","is-referenced-by-count":4,"title":["Resolution of EBV<sup>+<\/sup> CNS lymphoma with appearance of CSF EBV\u2010specific T cells"],"prefix":"10.1002","volume":"58","author":[{"given":"Janet W.","family":"de Beukelaar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelis","family":"van Arkel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin J.","family":"van den Bent","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mars B.","family":"van 't Veer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerard J.","family":"van Doornum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan J.","family":"Cornelissen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter A.","family":"Sillevis Smitt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan W.","family":"Gratama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,10,20]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20300"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2004.03.005"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.5.1549"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200205270-00014"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.7.2592"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)09672-1"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000058745.02123.6F"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-12-4287"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.274.5284.94"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.187.9.1383"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.22.12346-12351.2003"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10321"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.38.2.712-715.2000"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-05-1982"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0320(19961215)26:4<243::AID-CYTO2>3.0.CO;2-D"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.3109\/10428190109099335"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20339"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.8.4450"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20011692"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(05)70171-6"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.20640","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.20640","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T06:50:58Z","timestamp":1697439058000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.20640"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,10,20]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2005,11]]}},"alternative-id":["10.1002\/ana.20640"],"URL":"https:\/\/doi.org\/10.1002\/ana.20640","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,10,20]]}}}