{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:26:51Z","timestamp":1790875611225,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,11,28]],"date-time":"2005-11-28T00:00:00Z","timestamp":1133136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2005,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We conducted an event\u2010related functional magnetic resonance imaging experiment to better understand the potentially compensatory alternative brain networks activated by a clinically relevant face\u2010name association task in Alzheimer's disease (AD) patients and matched control subjects. We recruited 17 healthy subjects and 12 AD patients at an early stage of the disease. They underwent functional magnetic resonance imaging scanning in four sessions. Each of the sessions combined a \u201cstudy\u201d phase and a \u201ctest\u201d phase. Face\/name pairs were presented in each study phase, and subjects were asked to associate faces with names. In the test phase, a recognition task, faces seen in the study phase were presented each with four different names. The task required selection of appropriate previously associated names from the study phase. Responses were recorded for post hoc classification into those successfully or unsuccessfully encoded. There were significant differences between the groups in accuracy and reaction time. Comparison of correctly versus incorrectly encoded and recognized pairs in the two groups indicated bilateral hippocampal hypoactivation both when encoding and recognizing in the AD group. Moreover, patients showed bilateral hyperactivation of parts of the parietal and frontal lobes. We discuss whether hyperactivation of a frontoparietal network reflects compensatory strategies for failing associative memory in AD patients. Ann Neurol 2005;58:870\u2013879<\/jats:p>","DOI":"10.1002\/ana.20653","type":"journal-article","created":{"date-parts":[[2005,11,28]],"date-time":"2005-11-28T22:49:19Z","timestamp":1133218159000},"page":"870-879","source":"Crossref","is-referenced-by-count":137,"title":["Alzheimer's patients engage an alternative network during a memory task"],"prefix":"10.1002","volume":"58","author":[{"given":"J\u00e9r\u00e9mie","family":"Pariente","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna","family":"Cole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Henson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Clare","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angus","family":"Kennedy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Rossor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Cipoloti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mich\u00e8le","family":"Puel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Francois","family":"Demonet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francois","family":"Chollet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard S. J.","family":"Frackowiak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,28]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617702811067"},{"key":"e_1_2_5_3_2","unstructured":"ParienteJ ClareL HensonR FrackowiakR.Paired associative learning in healthy elderly volunteers. An event related fMRI study.2004. Poster presented during the Human Brain Mapping Congress. Budapest June 13\u201317 2004."},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3932(00)00144-5"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1077775"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.1047"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(03)00391-4"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1202"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)00496-1"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004010050508"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200008173430701"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.74.1.44"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.3.773"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1364-6613(00)01845-3"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg020"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.939"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.14.3.399"},{"key":"e_1_2_5_19_2","first-page":"1","volume-title":"Human brain function","author":"Frackowiak R","year":"2004"},{"key":"e_1_2_5_20_2","volume-title":"Co\u2010planar stereotaxic atlas of the human brain","author":"Talairach J","year":"1988"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.1037"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1159\/000074081"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2003.02883.x"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1159\/000051269"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1101\/SQB.1996.061.01.021"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.08.028"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8986.1988.tb01874.x"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.274.5284.114"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.290.5500.2315"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2235925100"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617702813248"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/121.4.611"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200103260-00013"},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-03-00986.2003"},{"key":"e_1_2_5_35_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.9.1291"},{"key":"e_1_2_5_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1042-3680(18)30306-1"},{"key":"e_1_2_5_37_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.6.2016"},{"key":"e_1_2_5_38_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.66.2.137"},{"key":"e_1_2_5_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2003.09.042"},{"key":"e_1_2_5_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(03)45021-8"},{"key":"e_1_2_5_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(02)00026-X"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.20653","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.20653","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T23:51:10Z","timestamp":1697500270000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.20653"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11,28]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005,12]]}},"alternative-id":["10.1002\/ana.20653"],"URL":"https:\/\/doi.org\/10.1002\/ana.20653","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,11,28]]}}}