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Profound CSF 5\u2010methyltetrahydrofolate deficiency was observed with normal blood folate values and decreased CSF\/serum folate ratio, suggesting a transport defect across the blood\u2013brain barrier. Folinic acid treatment was established, and after 1 year clinical response to folinic supplementation was remarkable, with almost normal white matter image.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>The clinical response after folinic therapy highlights the need for the study of cerebral folate deficiency in patients with mitochondrial disorders and white matter lesions. Ann Neurol 2006<\/jats:p><\/jats:sec>","DOI":"10.1002\/ana.20746","type":"journal-article","created":{"date-parts":[[2005,12,19]],"date-time":"2005-12-19T22:18:19Z","timestamp":1135030699000},"page":"394-398","source":"Crossref","is-referenced-by-count":137,"title":["Cerebral folate deficiency and leukoencephalopathy caused by a mitochondrial DNA 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