{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:29:41Z","timestamp":1790864981407,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,1,25]],"date-time":"2006-01-25T00:00:00Z","timestamp":1138147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Fondation Horlait-Dapsens"},{"DOI":"10.13039\/100001491","name":"Belgian American Educational Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100001491","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100004415","name":"NATO","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100004415","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NIH"},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"crossref"}]},{"name":"\u201cFondation L\u00e9on Fr\u00e9d\u00e9ricq\u201d"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate cerebral structure in Tourette's syndrome (TS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Voxel\u2010based morphometry study of high\u2010resolution MRIs in 31 TS patients compared with 31 controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Increased gray matter mainly in the left mesencephalon in 31 TS patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>This result constitutes strong and direct evidence supporting Devinsky's hypothesis (Devinsky O. Neuroanatomy of Gilles de la Tourette's syndrome. Possible midbrain involvement. Arch Neurol 1983;40:508\u2013514) according to which midbrain disturbances play an important pathogenic role in TS. 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