{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:06:33Z","timestamp":1791291993444,"version":"4.1.0"},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,3,10]],"date-time":"2006-03-10T00:00:00Z","timestamp":1141948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title><jats:styled-content><jats:italic>Objective<\/jats:italic><\/jats:styled-content><\/jats:title><jats:p>Leucine\u2010rich repeat kinase 2 (LRRK2) has been linked to Parkinson's disease. Our study explores the expression of <jats:italic>LRRK2<\/jats:italic> in human and rodent brain tissue.<\/jats:p><\/jats:sec><jats:sec><jats:title><jats:styled-content><jats:italic>Methods<\/jats:italic><\/jats:styled-content><\/jats:title><jats:p>We analyzed <jats:italic>LRRK2<\/jats:italic> gene activity at the cellular level using in situ hybridization.<\/jats:p><\/jats:sec><jats:sec><jats:title><jats:styled-content><jats:italic>Results<\/jats:italic><\/jats:styled-content><\/jats:title><jats:p>We found a high and strikingly specific expression of <jats:italic>LRRK2<\/jats:italic> mRNA in rodent striatum and parts of cortex and no signals in dopamine neurons. In human tissue, <jats:italic>LRRK2<\/jats:italic> mRNA was found in the corresponding brain areas caudatus and putamen at lower levels and dopamine neurons were also devoid of LRRK2 mRNA. Expression levels in striatal tissue did not differ between Parkinson's disease patients and control subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title><jats:styled-content><jats:italic>Interpretation<\/jats:italic><\/jats:styled-content><\/jats:title><jats:p>Unlike all other genes so far linked to Parkinson's disease, our results demonstrate that LRRK2 expression is particularly high in brain dopaminoceptive areas. Ann Neurol 2006<\/jats:p><\/jats:sec>","DOI":"10.1002\/ana.20808","type":"journal-article","created":{"date-parts":[[2006,3,10]],"date-time":"2006-03-10T21:50:21Z","timestamp":1142027421000},"page":"714-719","source":"Crossref","is-referenced-by-count":160,"title":["LRRK2 expression linked to dopamine\u2010innervated areas"],"prefix":"10.1002","volume":"59","author":[{"given":"Dagmar","family":"Galter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Westerlund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Carmine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Lindqvist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olof","family":"Sydow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Olson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,3,10]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.10.023"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.11.005"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00716936"},{"key":"e_1_2_6_5_2","volume-title":"Cellular expression of PINK1, implicated in Parkinson's disease, in human, rat and mouse tissues","author":"Blackinton JG","year":"2004"},{"key":"e_1_2_6_6_2","article-title":"DJ\u20101 and UCH\u2010L1 gene activity patterns in the brains of controls, Parkinson and schizophrenia patients and in rodents","author":"Galter D","year":"2005","journal-title":"Physiol Behav"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(200002)47:2<201::AID-ANA10>3.0.CO;2-F"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8257(200009)15:5<813::AID-MDS1008>3.0.CO;2-Y"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.62.1.74"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10172"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1042\/BST0330586"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(02)03396-6"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/122.8.1449"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-004-0956-9"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.20808","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.20808","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T23:39:59Z","timestamp":1697499599000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.20808"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3,10]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,4]]}},"alternative-id":["10.1002\/ana.20808"],"URL":"https:\/\/doi.org\/10.1002\/ana.20808","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,3,10]]}}}