{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T08:10:40Z","timestamp":1793175040608,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,2,17]],"date-time":"2006-02-17T00:00:00Z","timestamp":1140134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2006,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>\n                      <jats:styled-content>\n                        <jats:italic>Objective<\/jats:italic>\n                      <\/jats:styled-content>\n                    <\/jats:title>\n                    <jats:p>To characterize the association between infectious mononucleosis (IM), a frequent clinical manifestation of primary Epstein\u2013Barr virus infection after childhood, and the risk for multiple sclerosis (MS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\n                      <jats:styled-content>\n                        <jats:italic>Methods<\/jats:italic>\n                      <\/jats:styled-content>\n                    <\/jats:title>\n                    <jats:p>We conducted a systematic review and meta\u2010analysis of case\u2013control and cohort studies of IM and MS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\n                      <jats:styled-content>\n                        <jats:italic>Results<\/jats:italic>\n                      <\/jats:styled-content>\n                    <\/jats:title>\n                    <jats:p>\n                      The combined relative risk of MS after IM from 14 studies was 2.3 (95% confidence interval, 1.7\u20133.0;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 10\n                      <jats:sup>\u22128<\/jats:sup>\n                      ). Potential sources of heterogeneity (ie, study design, MS definition, and latitude) barely influenced our results.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\n                      <jats:styled-content>\n                        <jats:italic>Interpretation<\/jats:italic>\n                      <\/jats:styled-content>\n                    <\/jats:title>\n                    <jats:p>We conclude that Epstein\u2013Barr virus infection manifesting as IM in adolescents and young adults is a risk factor for MS. 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