{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T04:58:19Z","timestamp":1791089899376,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,5,22]],"date-time":"2006-05-22T00:00:00Z","timestamp":1148256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Susceptibility to exertional cramps and rhabdomyolysis in myophosphorylase deficiency (McArdle's disease [MD]) may lead patients to shun exercise. However, physical inactivity may worsen exercise intolerance by further reducing the limited oxidative capacity caused by blocked glycogenolysis. We investigated whether aerobic conditioning can safely improve exercise capacity in MD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eight MD patients (4 men and 4 women; age range, 33\u201361 years) pedaled a cycle ergometer for 30 to 40 minutes a day, 4 days a week, for 14 weeks, at an intensity corresponding to 60 to 70% of maximal heart rate. We monitored serum creatine kinase levels; changes in peak cycle work, oxygen uptake, and cardiac output; presence and magnitude of a spontaneous and glucose\u2010induced second wind; and citrate synthase and \u03b2\u2010hydroxyacyl coenzyme A dehydrogenase enzyme activities in quadriceps muscle.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prescribed exercise program increased average work capacity (36%), oxygen uptake (14%), cardiac output (15%), and citrate synthase and \u03b2\u2010hydroxyacyl coenzyme A dehydrogenase enzyme levels (80 and 62%, respectively) without causing pain or cramping or increasing serum creatine kinase. A spontaneous and glucose\u2010induced second wind was present and was of similar magnitude in each patient before and after training.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Moderate aerobic exercise is an effective means of improving exercise capacity in MD by increasing circulatory delivery and mitochondrial metabolism of bloodborne fuels. Ann Neurol 2006;59:922\u2010928<\/jats:p><\/jats:sec>","DOI":"10.1002\/ana.20881","type":"journal-article","created":{"date-parts":[[2006,5,22]],"date-time":"2006-05-22T22:27:02Z","timestamp":1148336822000},"page":"922-928","source":"Crossref","is-referenced-by-count":141,"title":["Aerobic conditioning: An effective therapy in McArdle's disease"],"prefix":"10.1002","volume":"59","author":[{"given":"Ronald G.","family":"Haller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phil","family":"Wyrick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Taivassalo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Vissing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,5,22]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"665","volume-title":"Myology","author":"Haller RG","year":"2004"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.59.9.1395"},{"key":"e_1_2_6_4_2","first-page":"555","volume-title":"Skeletal muscle adaptability: significance for metabolism and performance. Handbook of physiology. Skeletal muscle","author":"Saltin B","year":"1983"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.62.1.82"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/109.6.1087"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10725"},{"key":"e_1_2_6_8_2","first-page":"203","article-title":"Non\u2010invasive determination of cardiac output by a modified acetylene rebreathing procedure utilizing mass spectrometer","volume":"48","author":"Triebwasser JH","year":"1977","journal-title":"Aviat Space Environ Med"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg028"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1984.tb07414.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410270214"},{"key":"e_1_2_6_12_2","first-page":"13","article-title":"Myopathy due to a defect in muscle glycogen breakdown","volume":"10","author":"McArdle B","year":"1951","journal-title":"Clin Sci"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.2174\/1566524024605770"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003458.pub2"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198502073120607"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1990.tb01007.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.57.7.956"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.5.1456"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-8966(98)00004-2"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.59.1.97"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(95)00320-2"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.6.1352"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000194212.31318.fc"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031836"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410170216"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410360606"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199606)19:6<764::AID-MUS12>3.0.CO;2-L"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10499"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20251"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.scispo.2004.11.001"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114135"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115422"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.20881","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.20881","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T03:29:41Z","timestamp":1697513381000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.20881"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5,22]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,6]]}},"alternative-id":["10.1002\/ana.20881"],"URL":"https:\/\/doi.org\/10.1002\/ana.20881","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,5,22]]}}}