{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:10:39Z","timestamp":1791407439027,"version":"4.3.3"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,4,23]],"date-time":"2007-04-23T00:00:00Z","timestamp":1177286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>A proportion of patients with pure lower motor neuron syndrome (LMNS) progress to amyotrophic lateral sclerosis (ALS). Early detection of this progression is impossible, which delays the patient's access to treatment. Muscle expression of Nogo\u2010A is a new candidate marker of ALS. We tested whether detection of Nogo\u2010A in a muscle biopsy from patients with LMNS predicts progression to ALS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty\u2010three patients who had undergone a muscle biopsy during the diagnostic workup of spinal LMNS were observed for 12 months. Nogo\u2010A expression was measured by Western blot in muscle biopsy samples and compared with the final diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Nogo\u2010A expression was detected in 17 patients and was absent in 16 patients. The detection of Nogo\u2010A in muscle biopsy samples from LMNS patients correctly identified patients who further progressed to ALS with 91% accuracy, 94% sensitivity, and 88% specificity. In patients who later developed typical ALS, Nogo\u2010A may be detected as early as 3 months after the onset of symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Nogo\u2010A test is able to identify ALS early in the course of the disease when diagnosis is difficult, requiring further progression. Use of the test in clinical practice may shorten the delay before introduction of neuroprotective drugs or inclusion in clinical trials. Ann Neurol 2007<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ana.21122","type":"journal-article","created":{"date-parts":[[2007,4,23]],"date-time":"2007-04-23T17:21:56Z","timestamp":1177348916000},"page":"15-20","source":"Crossref","is-referenced-by-count":87,"title":["Muscle Nogo\u2010a expression is a prognostic marker in lower motor neuron syndromes"],"prefix":"10.1002","volume":"62","author":[{"given":"Pierre\u2010Fran\u00e7ois","family":"Pradat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaelle","family":"Bruneteau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose\u2010Luis","family":"Gonzalez de 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