{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:29:57Z","timestamp":1791260997431,"version":"4.1.0"},"reference-count":56,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,8,13]],"date-time":"2007-08-13T00:00:00Z","timestamp":1186963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Selective focal MR\u2010Signal (diffusion\u2010) changes in the CA\u20101 sector of the hippocampus have been described in transient global amnesia (TGA), but the pathophysiological substrate of these lesions is largely unknown. As several imaging and epidemiological findings point to a vascular origin an analysis of the temporal evolution of the hippocampal apparent diffusion coefficient (ADC) changes may offer new understanding of the pathomechanisms of TGA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The time course of the ADC of hippocampal DWI lesions in TGA patients was studied using serial 3 T high\u2010resolution MR\u2010imaging within 1\u201010 days as well as 4\u20106 months after TGA. ADC values from 76 MR\u2010studies were analyzed and expressed as ratio ADC (rADC) in reference to the unaffected hemisphere.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010nine patients with TGA showed 34 DWI lesions with corresponding T2 lesions in the CA\u20101 sector of the hippocampal cornu ammonis within a time window of 24\u201072 h after onset. Ratio ADC decreased below 1.0 (0.66 \u00b1 0.08) 24 h after the acute TGA episode and did show a further significant decrease to 0.57 \u00b1 0.1 after 3 days (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05). After 72 h, rADC increased and normalized around day 10 with rADC values of 1.0 (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>The temporal evolution of the rADC in hippocampal signal changes in TGA shows a time course previously described for ischemic lesions in human stroke patients. This might imply a vascular origin of diffusion changes leading to a transient perturbation of memory relevant circuits in the hippocampus. Ann Neurol 2007<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ana.21189","type":"journal-article","created":{"date-parts":[[2007,8,13]],"date-time":"2007-08-13T18:46:42Z","timestamp":1187030802000},"page":"475-480","source":"Crossref","is-referenced-by-count":73,"title":["Evolution of hippocampal CA\u20101 diffusion lesions in transient global amnesia"],"prefix":"10.1002","volume":"62","author":[{"given":"Thorsten","family":"Bartsch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karsten","family":"Alfke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guenther","family":"Deuschl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olav","family":"Jansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,8,13]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.53.10.834"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)01442-1"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(05)70121-6"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000130504.88404.C9"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2004.042432"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.28.11.2311"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.3.901"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl248"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000219620.69618.9d"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-005-0894-9"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03313-4"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1159\/000068501"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-001-0720-8"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2003.033852"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.58.10.1569"},{"key":"e_1_2_5_17_2","first-page":"261","article-title":"Diffusion\u2010weighted imaging patterns of brain damage associated with cerebral venous thrombosis","volume":"22","author":"Ducreux D","year":"2001","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1159\/000047634"},{"key":"e_1_2_5_19_2","first-page":"1666","article-title":"Parenchymal abnormalities associated with cerebral venous sinus thrombosis: assessment with diffusion\u2010weighted MR imaging","volume":"25","author":"Mullins ME","year":"2004","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_5_20_2","series-title":"Handbook of clinical neurology","first-page":"205","author":"Caplan L","year":"1985"},{"key":"e_1_2_5_21_2","first-page":"113","article-title":"Studies on the structure of the cerebral cortex. II. Continuation of the study of the ammonic system","volume":"46","author":"Lorente de No R","year":"1934","journal-title":"Journal f\u00fcr Psychologie und Neurologie"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/b138576"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528-1157.2001.19500.x"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh454"},{"key":"e_1_2_5_25_2","first-page":"1149","article-title":"Transient MR signal changes in patients with generalized tonicoclonic seizure or status epilepticus: periictal diffusion\u2010weighted imaging","volume":"22","author":"Kim JA","year":"2001","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_5_26_2","first-page":"1582","article-title":"Apparent diffusion coefficient measurements in the hippocampi in patients with temporal lobe seizures","volume":"24","author":"Londono A","year":"2003","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.29.9.1778"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.49.1.113"},{"key":"e_1_2_5_29_2","unstructured":"LutsepH AlbersG de CrespignyA MoseleyM.Diffusion imaging of human stroke. Proceedings of the International Society for Magnetic Resonance in Medicine. 4th scientific meeting 1996; New York."},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.29.11.2268"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.31.11.2723"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-7091-0651-8_31"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-004-0399-y"},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200010200-00014"},{"key":"e_1_2_5_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.05.018"},{"key":"e_1_2_5_36_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199611000-00033"},{"key":"e_1_2_5_37_2","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000170438.13677.22"},{"key":"e_1_2_5_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-003-1122-x"},{"key":"e_1_2_5_39_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-002-0881-3"},{"key":"e_1_2_5_40_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1789.2000.00306.x"},{"key":"e_1_2_5_41_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2000.83.2.1031"},{"key":"e_1_2_5_42_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2382142"},{"key":"e_1_2_5_43_2","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20068"},{"key":"e_1_2_5_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(91)90001-5"},{"key":"e_1_2_5_45_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1990.63.3.385"},{"key":"e_1_2_5_46_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1995.74.2.565"},{"key":"e_1_2_5_47_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199807000-00009"},{"key":"e_1_2_5_48_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.WCB.0000100852.67976.C2"},{"key":"e_1_2_5_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)71655-X"},{"key":"e_1_2_5_50_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.10.4750"},{"key":"e_1_2_5_51_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0406-05.2005"},{"key":"e_1_2_5_52_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-006-0143-7"},{"key":"e_1_2_5_53_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.5.1139"},{"key":"e_1_2_5_54_2","first-page":"155","article-title":"Diffusion\u2010weighted MR of the brain: methodology and clinical application","volume":"109","author":"Mascalchi M","year":"2005","journal-title":"Radiol Med (Torino)"},{"key":"e_1_2_5_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-6111(01)00005-2"},{"key":"e_1_2_5_56_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000218207.18707.f4"},{"key":"e_1_2_5_57_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.27.070203.144130"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.21189","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.21189","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T10:20:35Z","timestamp":1697451635000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.21189"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8,13]]},"references-count":56,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,11]]}},"alternative-id":["10.1002\/ana.21189"],"URL":"https:\/\/doi.org\/10.1002\/ana.21189","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1103060.559037","asserted-by":"object"}]},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,8,13]]}}}