{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T10:12:17Z","timestamp":1791886337139,"version":"4.3.4"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,5,21]],"date-time":"2008-05-21T00:00:00Z","timestamp":1211328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We determined whether serum cystatin C, a novel measure of kidney function that colocalizes with brain \u03b2\u2010amyloid, is associated with cognition among 3,030 elders. Those with high cystatin C (n = 445; 15%) had worse baseline scores on Modified Mini\u2010Mental State Examination or Digit Symbol Substitution Test (<jats:italic>p<\/jats:italic> \u2264 0.02) compared with those with intermediate\/low level and 7 years greater decline (<jats:italic>p<\/jats:italic> \u2264 0.04). Incident cognitive impairment (decline \u22651.0 standard deviation) was greatest among those with high cystatin C (Modified Mini\u2010Mental State Examination: 38 vs 25%; adjusted odds ratio, 1.92; 95% confidence interval, 1.37\u20132.69; Digit Symbol Substitution: 38 vs 26%; odds ratio, 1.54; 95% confidence interval, 1.10\u20132.15). Ann Neurol 2008<\/jats:p>","DOI":"10.1002\/ana.21383","type":"journal-article","created":{"date-parts":[[2008,5,21]],"date-time":"2008-05-21T19:58:18Z","timestamp":1211399898000},"page":"798-802","source":"Crossref","is-referenced-by-count":109,"title":["Cystatin C as a marker of cognitive function in elders: Findings from the health ABC study"],"prefix":"10.1002","volume":"63","author":[{"given":"Kristine","family":"Yaffe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karla","family":"Lindquist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Shlipak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleanor","family":"Simonsick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Fried","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Rosano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Satterfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hal","family":"Atkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. Gwen","family":"Windham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manjula","family":"Kurella\u2010Tamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,5,21]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2003.11.006"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.57.11.1579"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1159\/000100021"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/56.10.M644"},{"key":"e_1_2_6_6_2","first-page":"314","article-title":"The Modified Mini\u2010Mental State (3MS) examination","volume":"48","author":"Teng EL","year":"1987","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_6_7_2","volume-title":"Wechsler Adult Intelligence Scale","author":"Wechsler D","year":"1997"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365519950185940"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043161"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/014662167700100306"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(02)70054-1"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2006.12.016"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-142-7-200504050-00008"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2006.08.023"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000131529.60019.FA"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2004.52508.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2004.08.044"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005010005"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2004100854"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005010006"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)61781-6"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.21383","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.21383","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T08:51:40Z","timestamp":1697446300000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.21383"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5,21]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["10.1002\/ana.21383"],"URL":"https:\/\/doi.org\/10.1002\/ana.21383","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,5,21]]}}}