{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:03:59Z","timestamp":1791198239103,"version":"4.1.0"},"reference-count":151,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":2429,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Neurol."],"DOI":"10.1002\/ana.21473","type":"journal-article","created":{"date-parts":[[2010,7,9]],"date-time":"2010-07-09T12:04:45Z","timestamp":1278677085000},"page":"S122-S138","source":"Crossref","is-referenced-by-count":20,"special_numbering":"supplement 2","title":["Future of cell and gene therapies for Parkinson's disease"],"prefix":"10.1002","volume":"64","author":[{"given":"Ole","family":"Isacson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey H.","family":"Kordower","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,6]]},"reference":[{"key":"10.1002\/ana.21473-BIB1|cit1","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1056\/NEJM200103083441002","article-title":"Transplantation of embryonic dopamine neurons for severe Parkinson's disease","volume":"344","author":"Freed","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1002\/ana.21473-BIB2|cit2","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/88362","article-title":"Parkinson's disease: interpretations of transplantation study are erroneous","volume":"4","author":"Isacson","year":"2001","journal-title":"Nat Neurosci"},{"key":"10.1002\/ana.21473-BIB3|cit3","doi-asserted-by":"crossref","first-page":"589","DOI":"10.3171\/jns.2002.96.3.0589","article-title":"Simultaneous intrastriatal and intranigral fetal dopaminergic grafts in patients with Parkinson disease: a pilot study. Report of three cases","volume":"96","author":"Mendez","year":"2002","journal-title":"J Neurosurg"},{"key":"10.1002\/ana.21473-BIB4|cit4","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1038\/16060","article-title":"Dopamine release from nigral transplants visualized in vivo in a Parkinson's patient","volume":"2","author":"Piccini","year":"1999","journal-title":"Nat Neurosci"},{"key":"10.1002\/ana.21473-BIB5|cit5","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1002\/1531-8249(200011)48:5<689::AID-ANA1>3.0.CO;2-N","article-title":"Delayed recovery of movement-related cortical function in Parkinson's disease after striatal dopaminergic grafts","volume":"48","author":"Piccini","year":"2000","journal-title":"Ann Neurol"},{"key":"10.1002\/ana.21473-BIB6|cit6","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/ana.10720","article-title":"A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson's disease","volume":"54","author":"Olanow","year":"2003","journal-title":"Ann Neurol"},{"key":"10.1002\/ana.21473-BIB7|cit7","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1093\/brain\/awh510","article-title":"Cell type analysis of functional fetal dopamine cell suspension transplants in the striatum and substantia nigra of patients with Parkinson's disease","volume":"128","author":"Mendez","year":"2005","journal-title":"Brain"},{"key":"10.1002\/ana.21473-BIB8|cit8","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/ana.10482","article-title":"Towards full restoration of synaptic and terminal function of the dopaminergic system in Parkinson's disease from regeneration and neuronal replacement by stem cells","volume":"53","author":"Isacson","year":"2003","journal-title":"Ann Neurol"},{"key":"10.1002\/ana.21473-BIB9|cit9","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1056\/NEJM199504273321702","article-title":"Neuropathological evidence of graft survival and striatal reinnervation after the transplantation of fetal mesencephalic tissue in a patient with Parkinson's disease","volume":"332","author":"Kordower","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1002\/ana.21473-BIB10|cit10","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nm1747","article-title":"Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease","volume":"14","author":"Kordower","year":"2008","journal-title":"Nat Med"},{"key":"10.1002\/ana.21473-BIB11|cit11","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/nm1752","article-title":"Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years","volume":"14","author":"Mendez","year":"2008","journal-title":"Nat Med"},{"key":"10.1002\/ana.21473-BIB12|cit12","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/nm1746","article-title":"Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation","volume":"14","author":"Li","year":"2008","journal-title":"Nat Med"},{"key":"10.1002\/ana.21473-BIB13|cit13","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1073\/pnas.022438099","article-title":"Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model","volume":"99","author":"Bjorklund","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1002\/ana.21473-BIB14|cit14","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1093\/brain\/123.7.1365","article-title":"Embryonic ventral mesencephalic grafts improve levodopa-induced dyskinesia in a rat model of Parkinson's disease","volume":"123","author":"Lee","year":"2000","journal-title":"Brain"},{"key":"10.1002\/ana.21473-BIB15|cit15","unstructured":"Vinuela A Transplantation of dopamine transporter (DAT) KO ventral mesencephalic fetal cells in a rat model of Parkinson's disease; potential relevance to graft induced dyskinesias (Abstract)? 2005"},{"key":"10.1002\/ana.21473-BIB16|cit16","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0306-4522(87)90207-7","article-title":"Autoregulation of dopamine release and metabolism by intrastriatal nigral grafts as revealed by intracerebral dialysis","volume":"22","author":"Strecker","year":"1987","journal-title":"Neuroscience"},{"key":"10.1002\/ana.21473-BIB17|cit17","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0014-2999(84)90509-0","article-title":"Effects of apomorphine on the in vivo release of dopamine and its metabolites, studied by brain dialysis","volume":"97","author":"Zetterstrom","year":"1984","journal-title":"Eur J Pharmacol"},{"key":"10.1002\/ana.21473-BIB18|cit18","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S1474-4422(03)00437-X","article-title":"The production and use of cells as therapeutic agents in neurodegenerative diseases","volume":"2","author":"Isacson","year":"2003","journal-title":"Lancet Neurol"},{"key":"10.1002\/ana.21473-BIB19|cit19","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nature00900","article-title":"Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease","volume":"418","author":"Kim","year":"2002","journal-title":"Nature"},{"key":"10.1002\/ana.21473-BIB20|cit20","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1002\/cne.902400105","article-title":"Substantia nigra transplants into denervated striatum of the rat: ultrastructure of graft and host interconnections","volume":"240","author":"Mahalik","year":"1985","journal-title":"J Comp Neurol"},{"key":"10.1002\/ana.21473-BIB21|cit21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0014-4886(89)90139-8","article-title":"Host afferents into intrastriatal transplants of fetal ventral mesencephalon","volume":"106","author":"Doucet","year":"1989","journal-title":"Exp Neurol"},{"key":"10.1002\/ana.21473-BIB22|cit22","first-page":"62","article-title":"Treatment of severe Parkinson's disease by intraventricular injection of dopamine","volume":"47","author":"Venna","year":"1984","journal-title":"Appl Neurophysiol"},{"key":"10.1002\/ana.21473-BIB23|cit23","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/S1054-3589(08)60837-6","article-title":"Dopamine-mediated gene regulation in the striatum","volume":"42","author":"Gerfen","year":"1998","journal-title":"Adv Pharmacol"},{"key":"10.1002\/ana.21473-BIB24|cit24","doi-asserted-by":"crossref","first-page":"S45","DOI":"10.1016\/S1471-1931(00)00020-3","article-title":"Dopamine-mediated regulation of striatal neuronal and network interactions","volume":"23","author":"Onn","year":"2000","journal-title":"Trends Neurosci"},{"key":"10.1002\/ana.21473-BIB25|cit25","doi-asserted-by":"crossref","first-page":"S109","DOI":"10.1016\/S1471-1931(00)00029-X","article-title":"Continuous dopamine-receptor stimulation in advanced Parkinson's disease","volume":"23","author":"Nutt","year":"2000","journal-title":"Trends Neurosci"},{"key":"10.1002\/ana.21473-BIB26|cit26","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/0006-8993(85)91304-6","article-title":"Substantia nigra dopaminergic unit activity in behaving cats: effects of arousal on spontaneous discharge and sensory evoked activity","volume":"361","author":"Strecker","year":"1985","journal-title":"Brain Res"},{"key":"10.1002\/ana.21473-BIB27|cit27","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1152\/jn.1992.67.1.145","article-title":"Responses of monkey dopamine neurons during learning of behavioral reactions","volume":"67","author":"Ljungberg","year":"1992","journal-title":"J Neurophysiol"},{"key":"10.1002\/ana.21473-BIB28|cit28","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1016\/0024-3205(85)90448-5","article-title":"Firing properties of substantia nigra dopaminergic neurons in freely moving rats","volume":"36","author":"Freeman","year":"1985","journal-title":"Life Sci"},{"key":"10.1002\/ana.21473-BIB29|cit29","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1126\/science.1329209","article-title":"Burst firing in dopamine neurons induced by N-methyl-D-aspartate: role of electrogenic sodium pump","volume":"258","author":"Johnson","year":"1992","journal-title":"Science"},{"key":"10.1002\/ana.21473-BIB30|cit30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0306-4522(91)90196-U","article-title":"Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia","volume":"41","author":"Grace","year":"1991","journal-title":"Neuroscience"},{"key":"10.1002\/ana.21473-BIB31|cit31","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0166-2236(97)01081-3","article-title":"Neural transplantation studies reveal the brain's capacity for continuous reconstruction","volume":"20","author":"Isacson","year":"1997","journal-title":"Trends Neurosci"},{"key":"10.1002\/ana.21473-BIB32|cit32","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/0006-8993(86)90460-9","article-title":"In vivo measurement of spontaneous release and metabolism of dopamine from intrastriatal nigral grafts using intracerebral dialysis","volume":"362","author":"Zetterstrom","year":"1986","journal-title":"Brain Res"},{"key":"10.1002\/ana.21473-BIB33|cit33","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1002\/ana.410430318","article-title":"In vivo PET imaging in rat of dopamine terminals reveals functional neural transplants","volume":"43","author":"Brownell","year":"1998","journal-title":"Ann Neurol"},{"key":"10.1002\/ana.21473-BIB34|cit34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/exnr.1996.0109","article-title":"Xenotransplantation of porcine fetal ventral mesencephalon in a rat model of Parkinson's disease: functional recovery and graft morphology","volume":"140","author":"Galpern","year":"1996","journal-title":"Exp Neurol"},{"key":"10.1002\/ana.21473-BIB35|cit35","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/0006-8993(90)91215-3","article-title":"Fetal dopamine neuron transplants prevent behavioral supersensitivity induced by repeated administration of L-Dopa in the rat","volume":"506","author":"Gaudin","year":"1990","journal-title":"Brain Res"},{"key":"10.1002\/ana.21473-BIB36|cit36","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1002\/ana.410380307","article-title":"Bilateral fetal nigral transplantation into the postcommissural putamen in Parkinson's disease","volume":"38","author":"Freeman","year":"1995","journal-title":"Ann Neurol"},{"key":"10.1002\/ana.21473-BIB37|cit37","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1001\/archneur.1991.00530200062020","article-title":"Implantation of human fetal ventral mesencephalon to the right caudate nucleus in advanced Parkinson's disease","volume":"48","author":"Henderson","year":"1991","journal-title":"Arch Neurol"},{"key":"10.1002\/ana.21473-BIB38|cit38","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1001\/archneur.56.2.179","article-title":"Long-term evaluation of bilateral fetal nigral transplantation in Parkinson disease","volume":"56","author":"Hauser","year":"1999","journal-title":"Arch Neurol"},{"key":"10.1002\/ana.21473-BIB39|cit39","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/(SICI)1096-9861(19960624)370:2<203::AID-CNE6>3.0.CO;2-6","article-title":"Functional fetal nigral grafts in a patient with Parkinson's disease: chemoanatomic, ultrastructural, and metabolic studies","volume":"370","author":"Kordower","year":"1996","journal-title":"J Comp Neurol"},{"key":"10.1002\/ana.21473-BIB40|cit40","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1093\/hmg\/ddi178","article-title":"Cell type-specific gene expression of midbrain dopaminergic neurons reveals molecules involved in their vulnerability and protection","volume":"14","author":"Chung","year":"2005","journal-title":"Hum Mol Genet"},{"key":"10.1002\/ana.21473-BIB41|cit41","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0169-328X(94)90029-9","article-title":"Differential expression of tyrosine hydroxylase and membrane dopamine transporter genes in subpopulations of dopaminergic neurons of the rat mesencephalon","volume":"22","author":"Blanchard","year":"1994","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1002\/ana.21473-BIB42|cit42","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1523\/JNEUROSCI.10-03-00720.1990","article-title":"Patterns of cell and fiber vulnerability in the mesostriatal system of the mutant mouse weaver. I. Gradients and compartments","volume":"10","author":"Graybiel","year":"1990","journal-title":"J Neurosci"},{"key":"10.1002\/ana.21473-BIB43|cit43","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1006\/exnr.1995.1033","article-title":"Effects of glial cell line-derived neurotrophic factor on developing and mature ventral mesencephalic grafts in oculo","volume":"134","author":"Johansson","year":"1995","journal-title":"Exp Neurol"},{"key":"10.1002\/ana.21473-BIB44|cit44","doi-asserted-by":"crossref","first-page":"4078","DOI":"10.1073\/pnas.87.11.4078","article-title":"Specific reduction of calcium-binding protein (28-kilodalton calbindin-D) gene expression in aging and neurodegenerative diseases","volume":"87","author":"Iacopino","year":"1990","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1002\/ana.21473-BIB45|cit45","doi-asserted-by":"crossref","first-page":"13361","DOI":"10.1016\/S0021-9258(18)42219-3","article-title":"Molecular characterization of a novel metabotropic glutamate receptor, mGluR5, coupled to inositol phosphate\/Ca2+ signal transduction","volume":"267","author":"Abe","year":"1992","journal-title":"J Biol Chem"},{"key":"10.1002\/ana.21473-BIB46|cit46","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0006-8993(92)90719-P","article-title":"Melanin, tyrosine hydroxylase, calbindin and substance P in the human midbrain and substantia nigra in relation to nigrostriatal projections and differential neuronal susceptibility in Parkinson's disease","volume":"581","author":"Gibb","year":"1992","journal-title":"Brain Res"},{"key":"10.1002\/ana.21473-BIB47|cit47","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/0006-8993(90)91236-A","article-title":"Relative sparing in Parkinson's disease of substantia nigra dopamine neurons containing calbindin-D28K","volume":"526","author":"Yamada","year":"1990","journal-title":"Brain Res"},{"key":"10.1002\/ana.21473-BIB48|cit48","doi-asserted-by":"crossref","first-page":"6467","DOI":"10.1523\/JNEUROSCI.1676-05.2005","article-title":"Identification of dopaminergic neurons of nigral and ventral tegmental area subtypes in grafts of fetal ventral mesencephalon based on cell morphology, protein expression, and efferent projections","volume":"25","author":"Thompson","year":"2005","journal-title":"J Neurosci"},{"key":"10.1002\/ana.21473-BIB49|cit49","doi-asserted-by":"crossref","first-page":"3327","DOI":"10.1097\/00001756-199710200-00027","article-title":"Dopamine transporter mRNA levels are high in midbrain neurons vulnerable to MPTP","volume":"8","author":"Sanghera","year":"1997","journal-title":"Neuroreport"},{"key":"10.1002\/ana.21473-BIB50|cit50","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1002\/(SICI)1096-9861(19990621)409:1<38::AID-CNE4>3.0.CO;2-1","article-title":"Immunocytochemical localization of the dopamine transporter in human brain","volume":"409","author":"Ciliax","year":"1999","journal-title":"J Comp Neurol"},{"key":"10.1002\/ana.21473-BIB51|cit51","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1126\/science.1060645","article-title":"Dendrodendritic inhibition through reversal of dopamine transport","volume":"293","author":"Falkenburger","year":"2001","journal-title":"Science"},{"key":"10.1002\/ana.21473-BIB52|cit52","doi-asserted-by":"crossref","first-page":"4187","DOI":"10.1073\/pnas.89.9.4187","article-title":"Intrastriatal transplantation of cross-species fetal striatal cells reduces abnormal movements in a primate model of Huntington disease","volume":"89","author":"Hantraye","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1002\/ana.21473-BIB53|cit53","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0014-4886(90)90014-J","article-title":"A primate model of Huntington's disease: behavioral and anatomical studies of unilateral excitotoxic lesions of the caudate-putamen in the baboon","volume":"108","author":"Hantraye","year":"1990","journal-title":"Exp Neurol"},{"key":"10.1002\/ana.21473-BIB54|cit54","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/0306-4522(94)00431-4","article-title":"Selective putaminal excitotoxic lesions in non-human primates model the movement disorder of Huntington disease","volume":"64","author":"Burns","year":"1995","journal-title":"Neuroscience"},{"key":"10.1002\/ana.21473-BIB55|cit55","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1212\/WNL.54.5.1042","article-title":"Transplantation of embryonic porcine mesencephalic tissue in patients with Parkinson's disease","volume":"54","author":"Schumacher","year":"2000","journal-title":"Neurology"},{"key":"10.1002\/ana.21473-BIB56|cit56","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1038\/nm1195-1189","article-title":"Transplanted xenogeneic neural cells in neurodegenerative disease models exhibit remarkable axonal target specificity and distinct growth patterns of glial and axonal fibres","volume":"1","author":"Isacson","year":"1995","journal-title":"Nat Med"},{"key":"10.1002\/ana.21473-BIB57|cit57","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/0306-4522(96)00305-3","article-title":"Specific axon guidance factors persist in the mature rat brain: evidence from fetal neuronal xenografts","volume":"75","author":"Isacson","year":"1996","journal-title":"Neuroscience"},{"key":"10.1002\/ana.21473-BIB58|cit58","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1177\/096368979700600307","article-title":"Differential dissection of the rat E16 ventral mesencephalon and survival and reinnervation of the 6-OHDA-lesioned striatum by a subset of aldehyde dehydrogenase-positive TH neurons","volume":"6","author":"Haque","year":"1997","journal-title":"Cell Transplant"},{"key":"10.1002\/ana.21473-BIB59|cit59","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0896-6273(00)00079-9","article-title":"Embryonic stem cells go dopaminergic","volume":"28","author":"Hynes","year":"2000","journal-title":"Neuron"},{"key":"10.1002\/ana.21473-BIB60|cit60","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/nrn786","article-title":"Neural induction, the default model and embryonic stem cells","volume":"3","author":"Munoz-Sanjuan","year":"2002","journal-title":"Nat Rev Neurosci"},{"key":"10.1002\/ana.21473-BIB61|cit61","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1006\/exnr.1997.6674","article-title":"Blastula-stage stem cells can differentiate into dopaminergic and serotonergic neurons after transplantation","volume":"149","author":"Deacon","year":"1998","journal-title":"Exp Neurol"},{"key":"10.1002\/ana.21473-BIB62|cit62","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/76536","article-title":"Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells","volume":"18","author":"Lee","year":"2000","journal-title":"Nat Biotechnol"},{"key":"10.1002\/ana.21473-BIB63|cit63","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0896-6273(01)00263-X","article-title":"Direct neural fate specification from embryonic stem cells. A primitive mammalian neural stem cell stage acquired through a default mechanism","volume":"30","author":"Tropepe","year":"2001","journal-title":"Neuron"},{"key":"10.1002\/ana.21473-BIB64|cit64","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1634\/stemcells.2004-0294","article-title":"Cripto as a target for improving embryonic stem cell-based therapy in Parkinson's disease","volume":"23","author":"Parish","year":"2005","journal-title":"Stem Cells"},{"key":"10.1002\/ana.21473-BIB65|cit65","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1634\/stemcells.2006-0380","article-title":"Enhanced yield of neuroepithelial precursors and midbrain-like dopaminergic neurons from human embryonic stem cells using the bone morphogenic protein antagonist noggin","volume":"25","author":"Sonntag","year":"2007","journal-title":"Stem Cells"},{"key":"10.1002\/ana.21473-BIB66|cit66","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.tins.2006.09.003","article-title":"Molecular programming of stem cells into mesodiencephalic dopaminergic neurons","volume":"29","author":"Burbach","year":"2006","journal-title":"Trends Neurosci"},{"key":"10.1002\/ana.21473-BIB67|cit67","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.cell.2005.10.037","article-title":"Identification of intrinsic determinants of midbrain dopamine neurons","volume":"124","author":"Andersson","year":"2006","journal-title":"Cell"},{"key":"10.1002\/ana.21473-BIB68|cit68","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1046\/j.1471-4159.2003.01671.x","article-title":"The orphan nuclear receptor Nurr1 directly transactivates the promotor of the tyrosine hydroxylase gene in a cell-specific manner","volume":"85","author":"Kim","year":"2003","journal-title":"J Neurochem"},{"key":"10.1002\/ana.21473-BIB69|cit69","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1046\/j.1460-9568.2002.02255.x","article-title":"Genetic engineering of mouse embryonic stem cells by Nurr1 enhances differentiation and maturation into dopaminergic neurons","volume":"16","author":"Chung","year":"2002","journal-title":"Eur J Neurosci"},{"key":"10.1002\/ana.21473-BIB70|cit70","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1111\/j.1460-9568.2006.05093.x","article-title":"Transplanted dopamine neurons derived from primate ES cells preferentially innervate DARPP-32 striatal progenitors within the graft","volume":"24","author":"Ferrari","year":"2006","journal-title":"Eur J Neurosci"},{"key":"10.1002\/ana.21473-BIB71|cit71","doi-asserted-by":"crossref","first-page":"4271","DOI":"10.1523\/JNEUROSCI.18-11-04271.1998","article-title":"Characterization of intrastriatal recombinant adeno-associated virus-mediated gene transfer of human tyrosine hydroxylase and human GTP-cyclohydrolase I in a rat model of Parkinson's disease","volume":"18","author":"Mandel","year":"1998","journal-title":"J Neurosci"},{"key":"10.1002\/ana.21473-BIB72|cit72","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/S0140-6736(82)92797-0","article-title":"Basal ganglia disease","author":"Marsden","year":"1982","journal-title":"Lancet"},{"key":"10.1002\/ana.21473-BIB73|cit73","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0092-8674(00)81363-X","article-title":"Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF\/NGF receptor family","volume":"87","author":"Montgomery","year":"1996","journal-title":"Cell"},{"key":"10.1002\/ana.21473-BIB74|cit74","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1523\/JNEUROSCI.22-03-00614.2002","article-title":"Adult neurogenesis in mammals: an identity crisis","volume":"22","author":"Rakic","year":"2002","journal-title":"J Neurosci"},{"key":"10.1002\/ana.21473-BIB75|cit75","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1523\/JNEUROSCI.22-03-00629.2002","article-title":"Neurogenesis in adult subventricular zone","volume":"22","author":"Alvarez-Buylla","year":"2002","journal-title":"J Neurosci"},{"key":"10.1002\/ana.21473-BIB76|cit76","first-page":"S35","article-title":"Adenoviral transduction of the ventricular wall with a BDNF expression vector induces neuronal recruitment from endogenous progenitor cells in the adult forebrain","volume":"1","author":"Benraiss","year":"2000","journal-title":"Mol Ther"},{"key":"10.1002\/ana.21473-BIB77|cit77","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S0896-6273(00)00148-3","article-title":"Noggin antagonizes BMP signaling to create a niche for adult neurogenesis","volume":"28","author":"Lim","year":"2000","journal-title":"Neuron"},{"key":"10.1002\/ana.21473-BIB78|cit78","doi-asserted-by":"crossref","first-page":"7642","DOI":"10.1523\/JNEUROSCI.21-19-07642.2001","article-title":"The ciliary neurotrophic factor\/leukemia inhibitory factor\/gc130 receptor complex operates in the maintenance of mammalian forebrain neural stem cells","volume":"21","author":"Shimazaki","year":"2001","journal-title":"J Neurosci"},{"key":"10.1002\/ana.21473-BIB79|cit79","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1523\/JNEUROSCI.16-08-02649.1996","article-title":"In vivo growth factor expansion of endogenous subependymal neural precursor cell population in the adult mouse brain","volume":"16","author":"Craig","year":"1996","journal-title":"J Neurosci"},{"key":"10.1002\/ana.21473-BIB80|cit80","doi-asserted-by":"crossref","first-page":"14686","DOI":"10.1073\/pnas.97.26.14686","article-title":"In vivo induction of massive proliferation, directed migration, and differentiation of neural cells in the adult mammalian brain","volume":"97","author":"Fallon","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1002\/ana.21473-BIB81|cit81","doi-asserted-by":"crossref","first-page":"8924","DOI":"10.1523\/JNEUROSCI.2344-04.2004","article-title":"Intrastriatal transforming growth factor alpha delivery to a model of Parkinson's disease induces proliferation and migration of endogenous adult neural progenitor cells without differentiation into dopaminergic neurons","volume":"24","author":"Cooper","year":"2004","journal-title":"J Neurosci"},{"key":"10.1002\/ana.21473-BIB82|cit82","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/S0165-0173(01)00098-4","article-title":"Sustained delivery of GDNF: towards a treatment for Parkinson's disease","volume":"36","author":"Zurn","year":"2001","journal-title":"Brain Res"},{"key":"10.1002\/ana.21473-BIB83|cit83","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1046\/j.1471-4159.2001.00257.x","article-title":"Pitx3 activates mouse tyrosine hydroxylase promoter via a high-affinity binding site","volume":"77","author":"Lebel","year":"2001","journal-title":"J Neurochem"},{"key":"10.1002\/ana.21473-BIB84|cit84","doi-asserted-by":"crossref","first-page":"4013","DOI":"10.1073\/pnas.95.7.4013","article-title":"Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons","volume":"95","author":"Saucedo-Cardenas","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1002\/ana.21473-BIB85|cit85","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1006\/mcne.2001.1057","article-title":"Orphan nuclear receptor Nurr1 is essential for Ret expression in midbrain dopamine neurons and in the brain stem","volume":"18","author":"Wallen","year":"2001","journal-title":"Mol Cell Neurosci"},{"key":"10.1002\/ana.21473-BIB86|cit86","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0165-3806(01)00317-0","article-title":"Generation of tyrosine hydroxylase-immunoreactive neurons in ventral mesencephalic tissue of Nurr1 deficient mice","volume":"133","author":"Tornqvist","year":"2002","journal-title":"Brain Res Dev Brain Res"},{"key":"10.1002\/ana.21473-BIB87|cit87","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1111\/j.1460-9568.2004.03204.x","article-title":"Temporally induced Nurr1 can induce a non-neuronal dopaminergic cell type in embryonic stem cell differentiation","volume":"19","author":"Sonntag","year":"2004","journal-title":"Eur J Neurosci"},{"key":"10.1002\/ana.21473-BIB88|cit88","doi-asserted-by":"crossref","first-page":"8108","DOI":"10.1523\/JNEUROSCI.21-20-08108.2001","article-title":"Neuroprotection through delivery of glial cell line-derived neurotrophic factor by neural stem cells in a mouse model of Parkinson's disease","volume":"21","author":"Akerud","year":"2001","journal-title":"J Neurosci"},{"key":"10.1002\/ana.21473-BIB89|cit89","doi-asserted-by":"crossref","first-page":"5104","DOI":"10.1073\/pnas.91.11.5104","article-title":"Implanted fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevent 1-methyl-4-phenylpyridinium toxicity to dopaminergic neurons in rat","volume":"91","author":"Frim","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1002\/ana.21473-BIB90|cit90","doi-asserted-by":"crossref","first-page":"9126","DOI":"10.1523\/JNEUROSCI.20-24-09126.2000","article-title":"Protection by synergistic effects of adenovirus-mediated X-linked chromosome-linked inhibitor of apoptosis and glial-derived neurotrophic factor gene transfer in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease","volume":"20","author":"Eberhardt","year":"2002","journal-title":"J Neurosci"},{"key":"10.1002\/ana.21473-BIB91|cit91","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/exnr.1999.7056","article-title":"Apoptosis in neuronal development and transplantation: role of caspases and trophic factors","volume":"156","author":"Boonman","year":"1999","journal-title":"Exp Neurol"},{"key":"10.1002\/ana.21473-BIB92|cit92","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/0306-4522(91)90271-O","article-title":"Intracerebral implantation of nerve growth factor-producing fibroblasts protects striatum against neurotoxic levels of excitatory amino acids","volume":"45","author":"Schumacher","year":"1991","journal-title":"Neuroscience"},{"key":"10.1002\/ana.21473-BIB93|cit93","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1006\/exnr.1994.1004","article-title":"PET- and MRI-based assessment of glucose utilization, dopamine receptor binding, and hemodynamic changes after lesions to the caudate-putamen in primates","volume":"125","author":"Brownell","year":"1994","journal-title":"Exp Neurol"},{"key":"10.1002\/ana.21473-BIB94|cit94","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1002\/jnr.10396","article-title":"Neurospheres modified to produce glial cell line-derived neurotrophic factor increase the survival of transplanted dopamine neurons","volume":"69","author":"Ostenfeld","year":"2002","journal-title":"J Neurosci Res"},{"key":"10.1002\/ana.21473-BIB95|cit95","doi-asserted-by":"crossref","first-page":"452","DOI":"10.2337\/diab.32.5.452","article-title":"Normoglycemia after reflux of islet-containing pancreatic fragments into the splenic vascular bed in dogs","volume":"32","author":"Warnock","year":"1983","journal-title":"Diabetes"},{"key":"10.1002\/ana.21473-BIB96|cit96","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.2337\/diabetes.51.7.2148","article-title":"Successful islet transplantation: continued insulin reserve provides long-term glycemic control","volume":"51","author":"Ryan","year":"2002","journal-title":"Diabetes"},{"key":"10.1002\/ana.21473-BIB97|cit97","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nn1632","article-title":"Selective elimination of glutamatergic synapses on striatopallidal neurons in Parkinson disease models","volume":"9","author":"Day","year":"2006","journal-title":"Nat Neurosci"},{"key":"10.1002\/ana.21473-BIB98|cit98","doi-asserted-by":"crossref","first-page":"9011","DOI":"10.1073\/pnas.86.22.9011","article-title":"Grafting of fibroblasts genetically modified to produce l-dopa in a rat model of Parkinson's disease","volume":"86","author":"Wolff","year":"1989","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1002\/ana.21473-BIB99|cit99","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/ng1094-148","article-title":"Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain","volume":"8","author":"Kaplitt","year":"1994","journal-title":"Nat Genet"},{"key":"10.1002\/ana.21473-BIB100|cit100","doi-asserted-by":"crossref","first-page":"4708","DOI":"10.1073\/pnas.062047599","article-title":"Reversal of motor impairments in parkinsonian rats by continuous intrastriatal delivery of L-dopa using rAAV-mediated gene transfer","volume":"99","author":"Kirik","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1002\/ana.21473-BIB101|cit101","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1089\/10430340050083243","article-title":"Triple transduction with adeno-associated virus vectors expressing tyrosine hydroxylase, aromatic-L-amino-acid decarboxylase, and GTP cyclohydrolase I for gene therapy of Parkinson's disease","volume":"11","author":"Shen","year":"2000","journal-title":"Hum Gene Ther"},{"key":"10.1002\/ana.21473-BIB102|cit102","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1089\/10430340252792486","article-title":"Behavioral recovery in a primate model of Parkinson's disease by triple transduction of striatal cells with adeno-associated viral vectors expressing dopamine-synthesizing enzymes","volume":"13","author":"Muramatsu","year":"2002","journal-title":"Hum Gene Ther"},{"key":"10.1002\/ana.21473-BIB103|cit103","doi-asserted-by":"crossref","first-page":"8818","DOI":"10.1073\/pnas.94.16.8818","article-title":"Intrastriatal injection of an adenoviral vector expressing glial-cell-line-derived neurotrophic factor prevents dopaminergic neuron degeneration and behavioral impairment in a rat model of Parkinson disease","volume":"94","author":"Bilang-Bleuel","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1002\/ana.21473-BIB104|cit104","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1126\/science.275.5301.838","article-title":"Dopaminergic neurons protected from degeneration by GDNF gene therapy","volume":"275","author":"Choi-Lundberg","year":"1997","journal-title":"Science"},{"key":"10.1002\/ana.21473-BIB105|cit105","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1038\/sj.gt.3302222","article-title":"Delivery of GDNF by an E1,E3\/E4 deleted adenoviral vector and driven by a GFAP promoter prevents dopaminergic neuron degeneration in a rat model of Parkinson's disease","volume":"11","author":"Do Thi","year":"2004","journal-title":"Gene Ther"},{"key":"10.1002\/ana.21473-BIB106|cit106","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/1531-8257(200001)15:1<9::AID-MDS1004>3.0.CO;2-5","article-title":"Viral vectors in the treatment of Parkinson's disease","volume":"15","author":"Latchman","year":"2000","journal-title":"Mov Disord"},{"key":"10.1002\/ana.21473-BIB107|cit107","doi-asserted-by":"crossref","first-page":"261","DOI":"10.2165\/00002512-199914040-00003","article-title":"Therapeutic potential of nerve growth factors in Parkinson's disease","volume":"14","author":"Collier","year":"1999","journal-title":"Drugs Aging"},{"key":"10.1002\/ana.21473-BIB108|cit108","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1002\/1531-8249(199909)46:3<419::AID-ANA21>3.0.CO;2-Q","article-title":"Clinicopathological findings following intraventricular glial-derived neurotrophic factor treatment in a patient with Parkinson's disease","volume":"46","author":"Kordower","year":"1999","journal-title":"Ann Neurol"},{"key":"10.1002\/ana.21473-BIB109|cit109","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1212\/WNL.60.1.69","article-title":"Randomized, double-blind trial of glial cell line-derived neurotrophic factor (GDNF) in PD","volume":"60","author":"Nutt","year":"2003","journal-title":"Neurology"},{"key":"10.1002\/ana.21473-BIB110|cit110","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1159\/000017069","article-title":"Intracerebroventricular infusion of nerve growth factor in three patients with Alzheimer's disease","volume":"9","author":"Eriksdotter Jonhagen","year":"1998","journal-title":"Dement Geriatr Cogn Disord"},{"key":"10.1002\/ana.21473-BIB111|cit111","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/nm850","article-title":"Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease","volume":"9","author":"Gill","year":"2003","journal-title":"Nat Med"},{"key":"10.1002\/ana.21473-BIB112|cit112","doi-asserted-by":"crossref","first-page":"216","DOI":"10.3171\/jns.2005.102.2.0216","article-title":"Improvement of bilateral motor functions in patients with Parkinson disease through the unilateral intraputaminal infusion of glial cell line-derived neurotrophic factor","volume":"102","author":"Slevin","year":"2005","journal-title":"J Neurosurg"},{"key":"10.1002\/ana.21473-BIB113|cit113","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/nm0705-703","article-title":"Glial cell line-derived neurotrophic factor induces neuronal sprouting in human brain","volume":"11","author":"Love","year":"2005","journal-title":"Nat Med"},{"key":"10.1002\/ana.21473-BIB114|cit114","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1002\/ana.20737","article-title":"Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease","volume":"59","author":"Lang","year":"2006","journal-title":"Ann Neurol"},{"key":"10.1002\/ana.21473-BIB115|cit115","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/mds.20861","article-title":"Crossroads in GDNF therapy for Parkinson's disease","volume":"21","author":"Sherer","year":"2006","journal-title":"Mov Disord"},{"key":"10.1002\/ana.21473-BIB116|cit116","doi-asserted-by":"crossref","first-page":"3871","DOI":"10.1046\/j.1460-9568.2000.00274.x","article-title":"Preservation of a functional nigrostriatal dopamine pathway by GDNF in the intrastriatal 6-OHDA lesion model depends on the site of administration of the trophic factor","volume":"12","author":"Kirik","year":"2000","journal-title":"Eur J Neurosci"},{"key":"10.1002\/ana.21473-BIB117|cit117","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1006\/exnr.1998.6887","article-title":"Behavioral and cellular protection of rat dopaminergic neurons by an adenoviral vector encoding glial cell-line derived neurotrophic factor","volume":"154","author":"Choi-Lundberg","year":"1998","journal-title":"Exp Neurol"},{"key":"10.1002\/ana.21473-BIB118|cit118","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1038\/sj.gt.3301033","article-title":"Differential effects of glial cell line-derived neurotrophic factor (GDNF) in the striatum and substantia nigra of the aged Parkinsonian rat","volume":"6","author":"Connor","year":"1999","journal-title":"Gene Ther"},{"key":"10.1002\/ana.21473-BIB119|cit119","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1126\/science.290.5492.767","article-title":"Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease","volume":"290","author":"Kordower","year":"2000","journal-title":"Science"},{"key":"10.1002\/ana.21473-BIB120|cit120","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1006\/exnr.2001.7671","article-title":"Bcl-2 and GDNF delivered by HSV-mediated gene transfer act additively to protect dopaminergic neurons from 6-OHDA-induced degeneration","volume":"169","author":"Natsume","year":"2001","journal-title":"Exp Neurol"},{"key":"10.1002\/ana.21473-BIB121|cit121","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1126\/science.266.5189.1399","article-title":"Long-term behavioral recovery in parkinsonian rats by an HSV vector expressing tyrosine hydroxylase","volume":"266","author":"During","year":"1994","journal-title":"Science"},{"key":"10.1002\/ana.21473-BIB122|cit122","doi-asserted-by":"crossref","first-page":"4078","DOI":"10.1073\/pnas.96.7.4078","article-title":"Herpes simplex virus vector-mediated expression of bcl-2 prevents 6-hydroxydopamine-induced degeneration of neuron in the substantia nigra in vivo","volume":"96","author":"Yamada","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1002\/ana.21473-BIB123|cit123","doi-asserted-by":"crossref","first-page":"4686","DOI":"10.1523\/JNEUROSCI.20-12-04686.2000","article-title":"Long-term rAAV-mediated gene transfer of GDNF in the rat Parkinson's model: intrastriatal but not intranigral transduction promotes functional regeneration in the lesioned nigrostriatal system","volume":"20","author":"Kirik","year":"2000","journal-title":"J Neurosci"},{"key":"10.1002\/ana.21473-BIB124|cit124","doi-asserted-by":"crossref","first-page":"14083","DOI":"10.1073\/pnas.94.25.14083","article-title":"Midbrain injection of recombinant adeno-associated virus encoding rat glial cell line-derived neurotrophic factor protects nigral neurons in a progressive 6-hydroxydopamine-induced degeneration model of Parkinson's disease in rats","volume":"9","author":"Mandel","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1002\/ana.21473-BIB125|cit125","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/sj.gt.3301682","article-title":"Delayed delivery of AAV-GDNF prevents nigral neurodegeneration and promotes functional recovery in a rat model of Parkinson's disease","volume":"9","author":"Wang","year":"2002","journal-title":"Gene Ther"},{"key":"10.1002\/ana.21473-BIB126|cit126","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1111\/j.1460-9568.2005.04414.x","article-title":"Lentivector-mediated delivery of GDNF protects complex motor functions relevant to human Parkinsonism in a rat lesion model","volume":"22","author":"Dowd","year":"2005","journal-title":"Eur J Neurosci"},{"key":"10.1002\/ana.21473-BIB127|cit127","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1097\/00001756-200201210-00019","article-title":"Neuroprotection in the rat Parkinson model by intrastriatal GDNF gene transfer using a lentiviral vector","volume":"13","author":"Georgievska","year":"2002","journal-title":"Neuroreport"},{"key":"10.1002\/ana.21473-BIB128|cit128","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1006\/exnr.2002.8006","article-title":"Aberrant sprouting and downregulation of tyrosine hydroxylase in lesioned nigrostriatal dopamine neurons induced by long-lasting overexpression of glial cell line derived neurotrophic factor in the striatum by lentiviral gene transfer","volume":"177","author":"Georgievska","year":"2002","journal-title":"Exp Neurol"},{"key":"10.1002\/ana.21473-BIB129|cit129","doi-asserted-by":"crossref","first-page":"6437","DOI":"10.1523\/JNEUROSCI.1122-04.2004","article-title":"Overexpression of glial cell line-derived neurotrophic factor using a lentiviral vector induces time- and dose-dependent downregulation of tyrosine hydroxylase in the intact nigrostriatal dopamine system","volume":"24","author":"Georgievska","year":"2004","journal-title":"J Neurosci"},{"key":"10.1002\/ana.21473-BIB130|cit130","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1046\/j.1460-9568.2003.02456.x","article-title":"Long-term striatal overexpression of GDNF selectively downregulates tyrosine hydroxylase in the intact nigrostriatal dopamine system","volume":"17","author":"Rosenblad","year":"2003","journal-title":"Eur J Neurosci"},{"key":"10.1002\/ana.21473-BIB131|cit131","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1523\/JNEUROSCI.4421-04.2005","article-title":"Continuous low-level glial cell line-derived neurotrophic factor delivery using recombinant adeno-associated viral vectors provides neuroprotection and induces behavioral recovery in a primate model of Parkinson's disease","volume":"25","author":"Eslamboli","year":"2005","journal-title":"J Neurosci"},{"key":"10.1002\/ana.21473-BIB132|cit132","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.nbd.2004.06.008","article-title":"Lentiviral nigral delivery of GDNF does not prevent neurodegeneration in a genetic rat model of Parkinson's disease","volume":"17","author":"Lo Bianco","year":"2004","journal-title":"Neurobiol Dis"},{"key":"10.1002\/ana.21473-BIB133|cit133","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.brainresbull.2005.08.005","article-title":"Marmoset monkey models of Parkinson's disease: which model, when and why?","volume":"68","author":"Eslamboli","year":"2005","journal-title":"Brain Res Bull"},{"key":"10.1002\/ana.21473-BIB134|cit134","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/(SICI)1096-9861(19981116)401:2<253::AID-CNE7>3.0.CO;2-X","article-title":"Age-related declines in nigral neuronal function correlate with motor impairments in rhesus monkeys","volume":"401","author":"Emborg","year":"1998","journal-title":"J Comp Neurol"},{"key":"10.1002\/ana.21473-BIB135|cit135","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.nbd.2006.11.013","article-title":"Aging-related changes in the nigrostriatal dopamine system and the response to MPTP in nonhuman primates: diminished compensatory mechanisms as a prelude to parkinsonism","volume":"26","author":"Collier","year":"2007","journal-title":"Neurobiol Dis"},{"key":"10.1002\/ana.21473-BIB136|cit136","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.nbd.2006.08.021","article-title":"Age-associated increases of alpha-synuclein in monkeys and humans are associated with nigrostriatal dopamine depletion: is this the target for Parkinson's disease?","volume":"25","author":"Chu","year":"2007","journal-title":"Neurobiol Dis"},{"key":"10.1002\/ana.21473-BIB137|cit137","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1002\/cne.21333","article-title":"Age-related accumulation of Marinesco bodies and lipofuscin in monkey midbrain dopaminergic neurons: relevance to selective neuronal viability","volume":"502","author":"Kanaan","year":"2007","journal-title":"J Comp Neurol"},{"key":"10.1002\/ana.21473-BIB138|cit138","doi-asserted-by":"crossref","first-page":"4942","DOI":"10.1523\/JNEUROSCI.22-12-04942.2002","article-title":"Lentivirally delivered glial cell line-derived neurotrophic factor increases the number of striatal dopaminergic neurons in primate models of nigrostriatal degeneration","volume":"22","author":"Palfi","year":"2002","journal-title":"J Neurosci"},{"key":"10.1002\/ana.21473-BIB139|cit139","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/384467a0","article-title":"Neurturin, a relative of glial-cell-line-derived neurotrophic factor","volume":"384","author":"Kotzbauer","year":"1996","journal-title":"Nature"},{"key":"10.1002\/ana.21473-BIB140|cit140","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/S0896-6273(00)80318-9","article-title":"TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret","volume":"18","author":"Baloh","year":"1997","journal-title":"Neuron"},{"key":"10.1002\/ana.21473-BIB141|cit141","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/42729","article-title":"Neurturin responsiveness requires a GPI-linked receptor and the Ret receptor tyrosine kinase","volume":"387","author":"Buj-Bello","year":"1997","journal-title":"Nature"},{"key":"10.1002\/ana.21473-BIB142|cit142","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/1097-4547(20000701)61:1<1::AID-JNR1>3.0.CO;2-J","article-title":"Broad specificity of GDNF family receptors GFRalpha1 and GFRalpha2 for GDNF and NTN in neurons and transfected cells","volume":"61","author":"Wang","year":"2000","journal-title":"J Neurosci Res"},{"key":"10.1002\/ana.21473-BIB143|cit143","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.expneurol.2005.03.006","article-title":"Efficient in vivo protection of nigral dopaminergic neurons by lentiviral gene transfer of a modified Neurturin construct","volume":"195","author":"Fjord-Larsen","year":"2005","journal-title":"Exp Neurol"},{"key":"10.1002\/ana.21473-BIB144|cit144","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.nbd.2007.04.003","article-title":"AAV2-mediated delivery of human neurturin to the rat nigrostriatal system: long-term efficacy and tolerability of CERE-120 for Parkinson's disease","volume":"27","author":"Gasmi","year":"2007","journal-title":"Neurobiol Dis"},{"key":"10.1002\/ana.21473-BIB145|cit145","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1038\/mt.2008.170","article-title":"Transgene expression, bioactivity, and safety of CERE-120 (AAV2-neurturin) following delivery to the monkey striatum","volume":"16","author":"Herzog","year":"2008","journal-title":"Mol Ther"},{"key":"10.1002\/ana.21473-BIB146|cit146","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1002\/mds.21503","article-title":"Striatal delivery of AAV2-neurturin (CERE120) enhances activity of the dopaminergic nigrostriatal system in aged monkeys","volume":"22","author":"Herzog","year":"2007","journal-title":"Mov Disord"},{"key":"10.1002\/ana.21473-BIB147|cit147","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1002\/ana.21032","article-title":"Delivery of neurturin by AAV2 (CERE-120)-mediated gene transfer provides structural and functional neuroprotection and neurorestoration in MPTP-treated monkeys","volume":"60","author":"Kordower","year":"2006","journal-title":"Ann Neurol"},{"key":"10.1002\/ana.21473-BIB148|cit148","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1056\/NEJM200301163480314","article-title":"A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency","volume":"348","author":"Hacein-Bey-Abina","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1002\/ana.21473-BIB149|cit149","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/ng1179","article-title":"AAV serotype 2 vectors preferentially integrate into active genes in mice","volume":"34","author":"Nakai","year":"2003","journal-title":"Nat Genet"},{"key":"10.1002\/ana.21473-BIB150|cit150","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.ymgme.2003.08.016","article-title":"Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer","volume":"80","author":"Raper","year":"2003","journal-title":"Mol Genet Metab"},{"key":"10.1002\/ana.21473-BIB151|cit151","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/S0166-2236(96)80038-5","article-title":"Fetal nigral transplantation as a therapy for Parkinson's disease","volume":"19","author":"Olanow","year":"1996","journal-title":"Trends Neurosci"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.21473","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/ana.21473\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,31]],"date-time":"2021-10-31T04:43:17Z","timestamp":1635655397000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.21473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1,6]]},"references-count":151,"journal-issue":{"issue":"S2"},"URL":"https:\/\/doi.org\/10.1002\/ana.21473","relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1,6]]}}}