{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:32:39Z","timestamp":1791268359911,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,3,18]],"date-time":"2009-03-18T00:00:00Z","timestamp":1237334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2009,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>TDP\u201043 (TAR\u2010DNA binding protein) aggregates in neuronal inclusions in motoneuron disease (MND), as well as in frontotemporal lobar degeneration (FTLD) and FTLD associated with MND (FTLD\u2010MND). Mutations in <jats:italic>TARDBP<\/jats:italic> gene, coding for TDP\u201043, were found in patients with pure MND. We now describe <jats:italic>TARDBP<\/jats:italic> mutations in two patients with FTLD\u2010MND, presenting with a behavioral variant of FTLD and semantic dementia, suggesting that TDP\u201043 may also have a direct pathogenic role in FTLD disorders. Ann Neurol 2009;65:470\u2013474<\/jats:p>","DOI":"10.1002\/ana.21612","type":"journal-article","created":{"date-parts":[[2009,3,19]],"date-time":"2009-03-19T09:42:07Z","timestamp":1237455727000},"page":"470-473","source":"Crossref","is-referenced-by-count":274,"title":["<i>TARDBP<\/i> mutations in motoneuron disease with frontotemporal lobar degeneration"],"prefix":"10.1002","volume":"65","author":[{"given":"Lina","family":"Benajiba","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Le Ber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agn\u00e8s","family":"Camuzat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Lacoste","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Thomas\u2010Anterion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Couratier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solenn","family":"Legallic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Salachas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Hannequin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marielle","family":"Decousus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucette","family":"Lacomblez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Guedj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Golfier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Camu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Dubois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Campion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Meininger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Brice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"French Clinical and Genetic Research Network on Frontotemporal Lobar Degeneration\/Frontotemporal Lobar Degeneration with Motoneuron Disease","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,4,27]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.6.1546"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000055861.95202.8D"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1134108"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.69.6.3584-3596.1995"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M505557200"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21392"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21344"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1154584"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.132"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70071-1"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.65.9.1185"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000193"},{"key":"e_1_2_7_14_2","article-title":"Contribution of TARDBP mutations to sporadic amyotrophic lateral sclerosis","author":"Daoud H","journal-title":"J Med Genet"},{"key":"e_1_2_7_15_2","article-title":"Neuronal inclusion protein TDP\u201043 has no primary genetic role in FTD and ALS","author":"Gijselinck I","journal-title":"Neurobiol Aging"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002450"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(94)90191-0"},{"key":"e_1_2_7_18_2","first-page":"529","article-title":"Neuropsychological and scintigraphic aspects of frontotemporal dementia preceding amyotrophic lateral sclerosis","volume":"159","author":"Vercelletto M","year":"2003","journal-title":"Rev Neurol (Paris)"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm024"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1080\/17482960701381911"},{"key":"e_1_2_7_21_2","article-title":"Semantic dementia associated with amyotrophic lateral sclerosis","author":"de Souza LC","journal-title":"Rev Neurol (Paris)"},{"issue":"1","key":"e_1_2_7_22_2","first-page":"66","article-title":"Semantic dementia combined with motor neuron disease: a case\u2010report","volume":"26","author":"Kim SH","year":"2008","journal-title":"Dement Geriatr Cogn Dis"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2008.05.024"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.21612","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.21612","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T18:13:48Z","timestamp":1697480028000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.21612"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,4]]}},"alternative-id":["10.1002\/ana.21612"],"URL":"https:\/\/doi.org\/10.1002\/ana.21612","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,4]]}}}