{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T21:51:41Z","timestamp":1790459501665,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2009,3,18]],"date-time":"2009-03-18T00:00:00Z","timestamp":1237334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2009,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The polyomavirus JC (JCV) is the causative agent of progressive multifocal leukoencephalopathy and of JCV granule cell neuronopathy. We present a human immunodeficiency virus\u2013negative patient who experienced development of multiple cortical lesions, aphasia, and progressive cognitive decline after chemotherapy for non\u2013small\u2010cell lung cancer. Brain biopsy and cerebrospinal fluid polymerase chain reaction demonstrated JCV, and she had a rapidly fatal outcome. Postmortem analysis showed diffuse cortical lesions and areas of necrosis at the gray\u2013white junction. Immunostaining showed a productive JCV infection of cortical pyramidal neurons, confirmed by electron microscopy, with limited demyelination. This novel gray matter syndrome expands the scope of JCV clinical presentation and pathogenesis. Ann Neurol 2009;65:742\u2013748<\/jats:p>","DOI":"10.1002\/ana.21619","type":"journal-article","created":{"date-parts":[[2009,3,19]],"date-time":"2009-03-19T05:42:11Z","timestamp":1237441331000},"page":"742-748","source":"Crossref","is-referenced-by-count":116,"title":["Fulminant JC virus encephalopathy with productive infection of cortical pyramidal neurons"],"prefix":"10.1002","volume":"65","author":[{"given":"Christian","family":"W\u00fcthrich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Dang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Westmoreland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"McKay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atul","family":"Maheshwari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew P.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan H.","family":"Ropper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael P.","family":"Viscidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor J.","family":"Koralnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,6,25]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20933"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/13550280152537102"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000284601.54436.e4"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.81945-0"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000081306.86961.33"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20431"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.61.6.734"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01809-06"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.2.1347-1356.2003"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/13550280600716604"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.193.8.905"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e318180f0d5"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00206-08"},{"key":"e_1_2_5_15_2","first-page":"1896","article-title":"Progressive multifocal leukoencephalopathy in AIDS: are there any MR findings useful to patient management and predictive of patient survival?","volume":"20","author":"Post MJ","year":"1999","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/59.10.921"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.6.895"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1995.0001"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10523"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000194227.16696.11"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.21619","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.21619","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T17:13:50Z","timestamp":1697476430000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.21619"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["10.1002\/ana.21619"],"URL":"https:\/\/doi.org\/10.1002\/ana.21619","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,6]]}}}