{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T06:47:46Z","timestamp":1792738066285,"version":"4.5.0"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,7,20]],"date-time":"2009-07-20T00:00:00Z","timestamp":1248048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2009,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Encephalitis lethargica (EL) describes an encephalitis with psychiatric, sleep, and extrapyramidal movement disorders. Dyskinetic and Parkinsonian forms have been described. EL shares clinical features with the anti\u2013N\u2010methyl\u2010<jats:sc>D<\/jats:sc>\u2010aspartate receptor (NMDAR\u2010Ab) encephalitis. We studied 20 sera from pediatric patients with contemporary EL. Ten sera (from 2 males and 8 females, aged 1.3\u201313 years) and 6\/6 cerebrospinal fluid samples were positive for NMDAR\u2010Ab. NMDAR\u2010Ab\u2013positive patients had dyskinesias, agitation, seizures, and insomnia, whereas Parkinsonism and somnolence dominated in the NMDAR\u2010Ab\u2013negative children. We were unable to identify any tumors. The dyskinetic form of EL is an NMDAR\u2010Ab encephalitis and can affect very young children. Ann Neurol 2009;66:704\u2013709<\/jats:p>","DOI":"10.1002\/ana.21807","type":"journal-article","created":{"date-parts":[[2009,7,20]],"date-time":"2009-07-20T12:56:48Z","timestamp":1248094608000},"page":"704-709","source":"Crossref","is-referenced-by-count":191,"title":["N\u2010methyl\u2010<scp>D<\/scp>\u2010aspartate receptor antibodies in pediatric dyskinetic encephalitis lethargica"],"prefix":"10.1002","volume":"66","author":[{"given":"Russell C.","family":"Dale","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarosh R.","family":"Irani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabienne","family":"Brilot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sekhar","family":"Pillai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Webster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak","family":"Gill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bethan","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Vincent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,11,24]]},"reference":[{"key":"e_1_2_6_2_2","volume-title":"Encephalitis Lethargica, Its Sequelae and Treatment","author":"von Economo C","year":"1931"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21664"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2002.tb00804.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh008"},{"key":"e_1_2_6_6_2","first-page":"2","article-title":"A contemporary case of encephalitis lethargica","volume":"20","author":"Kiley M","year":"2001","journal-title":"Clin Neuropathol"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/110.1.19"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.46.6179"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870120314"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1997.tb00227.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)06208-9"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22073"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21050"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70224-2"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2005.10.014"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.65.7.913"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000327606.50322.f0"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2006.01.016"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000336648.43562.59"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2008.149021"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.21807","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.21807","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T05:49:41Z","timestamp":1697435381000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.21807"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["10.1002\/ana.21807"],"URL":"https:\/\/doi.org\/10.1002\/ana.21807","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,11]]}}}