{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T21:20:32Z","timestamp":1792876832076,"version":"4.5.0"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2009,8,11]],"date-time":"2009-08-11T00:00:00Z","timestamp":1249948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine whether lateral occipital complex (LOC) activation with functional magnetic resonance imaging (fMRI) predicts visual outcome after clinically isolated optic neuritis (ON). To investigate the reasons behind good recovery following ON, despite residual optic nerve demyelination and neuroaxonal damage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with acute ON and healthy volunteers were studied longitudinally over 12 months. Structural MRI, visual evoked potentials (VEPs), and optical coherence tomography (OCT) were used to quantify acute inflammation, demyelination, conduction block, and later to estimate remyelination and neuroaxonal loss over the entire visual pathway. The role of neuroplasticity was investigated using fMRI. Multivariable linear regression analysis was used to study associations between vision, structure, and function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Greater baseline fMRI responses in the LOCs were associated with better visual outcome at 12 months. This was evident on stimulation of either eye (<jats:italic>p<\/jats:italic> = 0.007 affected; <jats:italic>p<\/jats:italic> = 0.020 fellow eye), and was independent of measures of demyelination and neuroaxonal loss. A negative fMRI response in the LOCs at baseline was associated with a relatively worse visual outcome. No acute electrophysiological or structural measures, in the anterior or posterior visual pathways, were associated with visual outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Early neuroplasticity in higher visual areas appears to be an important determinant of recovery from ON, independent of tissue damage in the anterior or posterior visual pathway, including neuroaxonal loss (as measured by MRI, VEP, and OCT) and demyelination (as measured by VEP). ANN NEUROL 2010;67:99\u2013113<\/jats:p><\/jats:sec>","DOI":"10.1002\/ana.21823","type":"journal-article","created":{"date-parts":[[2009,8,11]],"date-time":"2009-08-11T16:51:50Z","timestamp":1250009510000},"page":"99-113","source":"Crossref","is-referenced-by-count":76,"title":["Neuroplasticity predicts outcome of optic neuritis independent of tissue damage"],"prefix":"10.1002","volume":"67","author":[{"given":"Thomas M.","family":"Jenkins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed T.","family":"Toosy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Ciccarelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine A.","family":"Miszkiel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia A.","family":"Wheeler\u2010Kingshott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew P.","family":"Henderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantinos","family":"Kallis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Mancini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon T.","family":"Plant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan J.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,2,23]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(03)00862-6"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00041327-199703000-00004"},{"key":"e_1_2_5_4_2","first-page":"284","article-title":"Optic neuritis as a sentinel lesion to study neuroprotection and repair in a trial of autologous mesenchymal stem cells in multiple sclerosis","volume":"14","author":"Kolappan M","year":"2008","journal-title":"Mult Scler"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1999.0510"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00874118"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh076"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.59.2.250"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh284"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf177"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20448"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.07.030"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm045"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-009-0123-z"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-004-0477-1"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf087"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000267272.60714.42"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20575"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20851"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1191\/1352458502ms809oa"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(82)90197-0"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/124.3.468"},{"key":"e_1_2_5_23_2","first-page":"277","article-title":"An investigation of the retinal nerve fibre layer in progressive multiple sclerosis using optical coherence tomography","volume":"131","author":"Henderson AP","year":"2008","journal-title":"Brain"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002340000450"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1177\/197140099200500413"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20905"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10609"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1075"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1998.0395"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1998.0396"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.200033797"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhg087"},{"key":"e_1_2_5_33_2","unstructured":"JenkinsTM ManciniL ToosyAT et al.A quadrant\u2010specific monocular visual functional MRI paradigm designed to minimize attention and loss\u2010of\u2010fixation biases(Abstract). ISMRM 16th Scientific Meeting and Exhibition Toronto Ontario Canada.2008;2460."},{"key":"e_1_2_5_34_2","first-page":"16","article-title":"Region\u2010of\u2010interest analysis using an SPM toolbox","volume":"2","author":"Brett M","year":"2002","journal-title":"Neuroimage"},{"key":"e_1_2_5_35_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.87.7.899"},{"key":"e_1_2_5_36_2","first-page":"65","article-title":"A simple sequentially rejective multiple test procedure","volume":"6","author":"Holm S","year":"1979","journal-title":"Scand J Stat"},{"key":"e_1_2_5_37_2","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.86.5.726"},{"key":"e_1_2_5_38_2","first-page":"841","article-title":"Descending optic nerve degeneration in primates","volume":"16","author":"Quigley HA","year":"1977","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_5_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21474"},{"key":"e_1_2_5_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2006.12.022"},{"key":"e_1_2_5_41_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.316.7139.1236"},{"key":"e_1_2_5_42_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199001000-00010"},{"key":"e_1_2_5_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(03)00165-4"},{"key":"e_1_2_5_44_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1990.00530110059017"},{"key":"e_1_2_5_45_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl100"},{"key":"e_1_2_5_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1361-8415(01)00036-6"},{"key":"e_1_2_5_47_2","doi-asserted-by":"publisher","DOI":"10.1109\/42.906424"},{"key":"e_1_2_5_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.08.051"},{"key":"e_1_2_5_49_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm152"},{"key":"e_1_2_5_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-2457(01)00561-2"},{"key":"e_1_2_5_51_2","first-page":"276","article-title":"Using structural and functional magnetic resonance imaging to explain visual loss at the onset of acute optic neuritis","volume":"14","author":"Jenkins TM","year":"2008","journal-title":"Mult Scler"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.21823","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.21823","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T03:14:21Z","timestamp":1697512461000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.21823"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["10.1002\/ana.21823"],"URL":"https:\/\/doi.org\/10.1002\/ana.21823","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,1]]}}}