{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T17:59:38Z","timestamp":1760983178817},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,10,13]],"date-time":"2009-10-13T00:00:00Z","timestamp":1255392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2010,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We evaluated the arginine growth hormone (GH) stimulation test for the diagnosis of cerebellar\u2010type multiple system atrophy (MSAc) in patients with ataxia. Fourteen subjects with MSAc, 11 with idiopathic late\u2010onset cerebellar ataxia (ILOCA), 10 with familial ataxia, and 10 healthy controls were tested. After pituitary GH deficiency was excluded, subjects underwent arginine testing. Peak serum GH response was analyzed. No significant differences in peak GH response were found between subject populations. Thirty\u2010three percent of MSAc subjects mounted responses &gt;10\u03bcg\/l GH. Thirty\u2010six percent of ILOCA subjects and 40 percent of healthy controls mounted responses &lt;4\u03bcg\/l GH. Arginine thus appears to be unreliable for the diagnosis of MSAc. ANN NEUROL 2010;67:404\u2013408<\/jats:p>","DOI":"10.1002\/ana.21898","type":"journal-article","created":{"date-parts":[[2009,10,14]],"date-time":"2009-10-14T00:34:10Z","timestamp":1255480450000},"page":"404-408","source":"Crossref","is-referenced-by-count":6,"title":["Arginine test is not reliable for diagnosing cerebellar multiple system atrophy"],"prefix":"10.1002","volume":"67","author":[{"given":"Raquel C.","family":"Gardner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy D.","family":"Schmahmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,3,29]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"262","volume-title":"Movement Disorders III","author":"Quinn N","year":"1994"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf107"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.4.527"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-007-0556-1"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2005.02237.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20956"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1999.79.2.511"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.19.6.717"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1992.tb04047.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.59.6.944"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000324625.00404.15"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(98)00247-0"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa033447"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.5.8509"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22681"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.01967"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1450"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1420347"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21032"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1986.tb07976.x"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.21898","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.21898","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T02:50:13Z","timestamp":1697511013000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.21898"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["10.1002\/ana.21898"],"URL":"https:\/\/doi.org\/10.1002\/ana.21898","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3]]}}}